RMI2 抗体 (AA 23-147)
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Quick Overview for RMI2 抗体 (AA 23-147) (ABIN7872481)
抗原
See all RMI2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 23-147
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原理
- RMI2 Antibody / BLAP18 / RecQ-mediated genome instability protein 2
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纯化方法
- Antigen affinity chromatography
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免疫原
- An E.coli-derived human recombinant protein (amino acids L23-P147) was used as the immunogen for the RMI2 antibody.
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亚型
- IgG
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anti-RMI2, RecQ Mediated Genome Instability 2 (RMI2) (AA 1-147) antibody
RMI2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-RMI2, RecQ Mediated Genome Instability 2 (RMI2) (AA 23-147) antibodyRMI2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-RMI2, RecQ Mediated Genome Instability 2 (RMI2) antibodyRMI2 适用: 人, 小鼠, 大鼠 WB, FACS, ICC, IHC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the RMI2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the RMI2 Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- RMI2 (RMI2, RecQ Mediated Genome Instability 2 (RMI2))
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别名
- RMI2
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背景
- RMI2 is a component of the BLM (RECQL3) complex, which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability. This gene is mapped to 16p13.13. RMI1 and RMI2 were present in approximately stoichiometric amounts with other BLM complex components, including topoisomerase-3-alpha (TOP3A), RPA (see RPA1), and BLAP250. RMI2 also associated with RMI1 and TOP3A in a second complex. RMI1 and RMI2 interacted directly, and both were essential for stability of the BLM complex. Depletion of either RMI1 or RMI2 depleted the other protein by 80 to 90 % . Chicken DT40 cells depleted of Rmi2 displayed elevated sister chromatid exchange, but other functions of the BLM complex appeared intact. Mutation analysis revealed that interaction between human RMI2 and BLM was essential for suppression of sister chromatid exchange.
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UniProt
- Q96E14
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途径
- DNA Damage Repair
抗原
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