Growth Hormone 1 抗体 (AA 22-217)
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Quick Overview for Growth Hormone 1 抗体 (AA 22-217) (ABIN7872313)
抗原
See all Growth Hormone 1 (GH1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 22-217
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原理
- GH1 Antibody / Growth Hormone
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human GH1 recombinant protein (Position: Q22-F217) was used as the immunogen for the GH1 antibody.
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亚型
- IgG
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anti-Growth Hormone 1 (GH1) antibody
GH1 适用: 人 IHC 宿主: 小鼠 Monoclonal GH-3155 unconjugated
anti-Growth Hormone 1 (GH1) (AA 28-217) antibodyGH1 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Growth Hormone 1 (GH1) (AA 58-187) antibodyGH1 适用: 人 IHC 宿主: 小鼠 Monoclonal GH-1371 unconjugated
anti-Growth Hormone 1 (GH1) (AA 1-217) antibodyGH1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 3H1C2 unconjugated
anti-Growth Hormone 1 (GH1) (AA 28-216) antibodyGH1 适用: 大鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Growth Hormone 1 (GH1) (AA 1-217) antibodyGH1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 8G6 unconjugated
anti-Growth Hormone 1 (GH1) antibodyGH1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Growth Hormone 1 (GH1) (AA 28-216) antibodyGH1 适用: 小鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Growth Hormone 1 (GH1) (AA 27-216) antibodyGH1 适用: 犬 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the GH1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the GH1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Growth Hormone 1 (GH1)
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别名
- GH1
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背景
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GH1 antibody detects Growth hormone 1, a peptide hormone secreted by the anterior pituitary gland that stimulates growth, metabolism, and cellular regeneration. GH1 belongs to the somatotropin/prolactin family of hormones and exerts its effects through activation of the growth hormone receptor (GHR) and downstream JAK-STAT signaling pathways. The GH1 antibody is used in endocrinology and metabolic research to study growth regulation, pituitary physiology, and hormone secretion mechanisms.
GH1 is encoded by the GH1 gene located on human chromosome 17q24.2. The mature protein is approximately 22 kilodaltons and derived from a larger precursor that undergoes signal peptide removal and disulfide bond formation in the endoplasmic reticulum. GH1 is stored in secretory granules and released into circulation in response to hypothalamic growth hormone-releasing hormone (GHRH) and inhibited by somatostatin. It plays major roles in postnatal growth, bone development, and metabolic homeostasis.
The GH1 antibody detects the 22 kilodalton hormone by western blot and shows strong cytoplasmic granule staining in pituitary somatotrophs by immunofluorescence. GH1 binds to its receptor on target tissues, activating JAK2 and STAT5 pathways that induce insulin-like growth factor 1 (IGF1) production in the liver and peripheral tissues. Through IGF1 and direct signaling, GH1 stimulates protein synthesis, lipolysis, and glucose utilization.
Aberrations in GH1 production cause growth disorders, including gigantism and acromegaly from overproduction, or growth hormone deficiency due to pituitary malfunction or genetic mutation. Outside growth regulation, GH1 contributes to immune function, cardiac performance, and metabolic adaptation under stress conditions. Elevated GH1 and IGF1 signaling are also linked to cancer cell proliferation and survival.
Because of its central endocrine function, GH1 serves as a key biomarker in clinical diagnostics and metabolic studies. NSJ Bioreagents provides a validated GH1 antibody optimized for western blot, flow cytometry, and hormone localization assays, supporting detailed investigation of pituitary function, growth signaling, and endocrine regulation. -
UniProt
- P01241
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途径
- NF-kappaB Signaling, JAK/STAT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Response to Growth Hormone Stimulus, Regulation of Hormone Biosynthetic Process
抗原
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