MERTK 抗体 (AA 21-489)
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Quick Overview for MERTK 抗体 (AA 21-489) (ABIN7872177)
抗原
See all MERTK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 21-489
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原理
- MerTK Antibody
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纯化方法
- Affinity purified
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免疫原
- An E. coli-derived human protein (amino acids A21-A489) was used as the immunogen for the MerTK antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the MerTK antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the MerTK antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))
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别名
- MerTK
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背景
- Proto-oncogene tyrosine-protein kinase MER, also called MERTK is an enzyme that in humans is encoded by the MERTK gene. This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type(immunoglobulin-like) domains, and one tyrosine kinase domain. This gene is mapped to 2q13. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. This gene is also very important in inhibition of Toll-like receptors(TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
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UniProt
- Q12866
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途径
- RTK signaling
抗原
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