Thrombospondin 1 抗体 (AA 19-268)
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Quick Overview for Thrombospondin 1 抗体 (AA 19-268) (ABIN7871580)
抗原
See all Thrombospondin 1 (THBS1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 19-268
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原理
- THBS1 Antibody / Thrombospondin
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纯化方法
- Affinity purified
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免疫原
- Recombinant human protein (amino acids N19-A268) was used as the immunogen for the THBS1 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the THBS1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the THBS1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Thrombospondin 1 (THBS1)
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别名
- THBS1
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背景
- THBS1 is also known as Thrombospondin 1, TSP1. The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. It is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Also this protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. In addition, the thrombospondin-1 protein is a member of the thrombospondinfamily. It is a multi-domain matrix glycoprotein that has been shown to be a natural inhibitor of neovascularization and tumorigenesis in healthy tissue. Both positive and negative modulation of endothelial cell adhesion, motility, and growth have been attributed to TSP1. This should not be surprising considering that TSP1 interacts with at least 12 cell adhesion receptors, including CD36, ?v integrins, ?1 integrins, syndecan, and integrin-associated protein (IAP or CD47). It also interacts with numerous proteases involved in angiogenesis, including plasminogen, urokinase, matrix metalloproteinase, thrombin, cathepsin, and elastase.
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UniProt
- P07996
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途径
- Autophagy
抗原
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