MUTYH 抗体 (AA 187-528)
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Quick Overview for MUTYH 抗体 (AA 187-528) (ABIN7871513)
抗原
See all MUTYH 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 187-528
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原理
- MUTYH Antibody / Adenine DNA glycosylase / MYH1
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纯化方法
- Antigen affinity purified
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免疫原
- An E.coli-derived human recombinant protein (amino acids A187-N528) was used as the immunogen for the MUTYH antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the MUTYH antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the MUTYH antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MUTYH (MutY Homolog (E. Coli) (MUTYH))
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别名
- MUTYH
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背景
- This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene.
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UniProt
- Q9UIF7
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途径
- DNA Damage Repair
抗原
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