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BIM 抗体 (AA 18-186)

Name: BIM 抗体 (AA 18-186)
SKU: ABIN7871398
Availability: OutOfStock

The 兔多克隆 anti-BIM antibody (ABIN7871398) specifically detects BIM in WB, ELISA 和 FACS. The antibody is reactive with 小鼠 samples.

产品编号 ABIN7871398

发货至: 中国

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Quick Overview for BIM 抗体 (AA 18-186) (ABIN7871398)

抗原

See all BIM (BCL2L11) 抗体

BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

适用

小鼠

宿主

兔

克隆类型

多克隆

标记

This BIM antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Discover our top product BCL2L11 Primary Antibody

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AA 18-186

原理

Bim Antibody / Bcl-2-like protein 11

纯化方法

Immunogen affinity purified

免疫原

E.coli-derived mouse Bim/Bcl2l11 recombinant protein (Position: Q18-R186) was used as the immunogen for the Bim antibody.

亚型

IgG
anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 2-120) antibody
BCL2L11 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 134-160) antibody
BCL2L11 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22105 unconjugated

anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (pSer87) antibody
BCL2L11 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 1-198) antibody
BCL2L11 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) antibody
KO Validated BCL2L11 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB610 unconjugated Recombinant Antibody

anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 130-165) antibody
BCL2L11 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB00963 unconjugated

anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (Middle Region) antibody
BCL2L11 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated

anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (AA 51-150) antibody
BCL2L11 适用: 人, 小鼠 WB, ELISA, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (pSer69) antibody
BCL2L11 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (pSer69) antibody
BCL2L11 适用: 人, 小鼠, 大鼠, Cow, 绵羊 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal dilution of the Bim antibody should be determined by the researcher.

限制

仅限研究用
状态

Lyophilized

溶解方式

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

缓冲液

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

储存条件

4 °C,-20 °C

储存方法

After reconstitution, the Bim antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
抗原

BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

别名

Bim

背景

Bim antibody detects Bcl-2-like protein 11, a pro-apoptotic member of the Bcl-2 family that promotes programmed cell death through mitochondrial outer membrane permeabilization. The UniProt recommended name is Bcl-2-like protein 11 (BCL2L11). Also known as Bim, this BH3-only protein is a critical initiator of apoptosis in response to cellular stress, cytokine withdrawal, or DNA damage.

Functionally, Bim antibody identifies a 198-amino-acid cytoplasmic protein that binds anti-apoptotic Bcl-2 proteins (such as BCL2, BCL-XL, and MCL1), releasing pro-apoptotic effectors BAX and BAK to trigger mitochondrial cytochrome c release and caspase activation. Bim exists in several isoforms (BimEL, BimL, and BimS) generated by alternative splicing, which modulate apoptosis sensitivity across cell types.

The BCL2L11 gene is located on chromosome 2q13 and is expressed in lymphoid, neuronal, and epithelial tissues. Its expression is tightly regulated by survival pathways including PI3K/AKT and MAPK signaling, which control phosphorylation and proteasomal degradation of Bim.

Pathologically, dysregulation of Bim contributes to cancer, autoimmune diseases, and neurodegeneration. Reduced Bim expression confers resistance to apoptosis in tumor cells, while overexpression causes excessive neuronal death. Research using Bim antibody supports studies in cell death signaling, oncology, and stress-induced apoptosis.

Bim antibody is validated for western blotting, immunohistochemistry, and apoptosis assays to detect Bcl-2 family proteins. NSJ Bioreagents provides Bim antibody reagents optimized for apoptosis research, mitochondrial biology, and cancer cell signaling.

Structurally, Bcl-2-like protein 11 contains a BH3 domain required for binding to anti-apoptotic Bcl-2 members and activating the intrinsic apoptotic pathway. This antibody supports exploration of Bim's role in stress-induced mitochondrial apoptosis and cellular homeostasis.

UniProt

O54918

途径

PI3K-Akt Signaling, Neurotrophin Signaling Pathway, Tube Formation, Positive Regulation of Endopeptidase Activity