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Recombinant Topoisomerase II alpha 抗体 (AA 1431-1531)

The 兔 单克隆 anti-Topoisomerase II alpha antibody is suitable to detect Topoisomerase II alpha in samples from 人 和 犬. It has been validated for IHC (p).
产品编号 ABIN7870710
发货至: 中国
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Quick Overview for Recombinant Topoisomerase II alpha 抗体 (AA 1431-1531) (ABIN7870710)

抗原

See all Topoisomerase II alpha (TOP2A) 抗体
Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

抗体类型

Recombinant Antibody

适用

  • 191
  • 85
  • 46
  • 8
  • 6
  • 3
  • 3
  • 3
  • 1
人, 犬

宿主

  • 140
  • 52

克隆类型

  • 99
  • 93
单克隆

标记

  • 119
  • 10
  • 6
  • 6
  • 6
  • 6
  • 6
  • 6
  • 4
  • 3
  • 3
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  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This Topoisomerase II alpha antibody is un-conjugated

应用范围

  • 133
  • 92
  • 52
  • 52
  • 39
  • 23
  • 18
  • 9
  • 1
  • 1
  • 1
  • 1
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

质量等级

Carrier-free

克隆位点

TOP2A-7169R
  • 抗原表位

    • 30
    • 15
    • 13
    • 11
    • 10
    • 9
    • 8
    • 7
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1431-1531

    原理

    Topoisomerase II alpha Antibody / TOP2A (azide and preservative free)

    纯化方法

    Protein A/G affinity

    免疫原

    A recombinant partial protein sequence (within amino acids 1431-1531) from the human protein was used as the immunogen for the Topoisomerase II alpha antibody.

    亚型

    IgG, kappa
  • 应用备注

    Optimal dilution of the Topoisomerase II alpha antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    -20 °C

    储存方法

    Aliquot the Topoisomerase II alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

    别名

    Topoisomerase II alpha

    背景

    The topoisomerase II-Alpha isoform is a 170 kDa nuclear protein and plays an important role in DNA synthesis and RNA transcription, as well as chromosomal segregation during mitosis. Topoisomerase II-Alpha is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells, and has been shown to be over-expressed in many human cancers. Decreased expression of Topoisomerase II-Alpha is the predominant mechanism of resistance to several chemotherapeutic agents.

    UniProt

    P11388

    途径

    Cell Division Cycle, Mitotic G1-G1/S Phases
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