HPD 抗体 (AA 12-357)
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Quick Overview for HPD 抗体 (AA 12-357) (ABIN7870289)
抗原
See all HPD 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 12-357
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原理
- HPD Antibody / 4HPPD / 4-hydroxyphenylpyruvate dioxygenase
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纯化方法
- Antigen affinity purified
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免疫原
- A human recombinant partial protein (amino acids E12-Q357) was used as the immunogen for the HPD antibody.
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亚型
- IgG
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anti-4-Hydroxyphenylpyruvate Dioxygenase (HPD) (AA 2-393) antibody
HPD 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-4-Hydroxyphenylpyruvate Dioxygenase (HPD) (AA 1-393) antibodyHPD 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-4-Hydroxyphenylpyruvate Dioxygenase (HPD) antibodyKO Validated HPD 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-4-Hydroxyphenylpyruvate Dioxygenase (HPD) (AA 92-121), (N-Term) antibodyHPD 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB17892 unconjugated
anti-4-Hydroxyphenylpyruvate Dioxygenase (HPD) (AA 160-269) antibodyHPD 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F3 unconjugated
anti-4-Hydroxyphenylpyruvate Dioxygenase (HPD) (AA 2-393) antibodyHPD 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-4-Hydroxyphenylpyruvate Dioxygenase (HPD) (AA 255-284), (C-Term) antibodyHPD 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB21004 unconjugated
anti-4-Hydroxyphenylpyruvate Dioxygenase (HPD) antibodyHPD 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-4-Hydroxyphenylpyruvate Dioxygenase (HPD) (C-Term) antibodyHPD 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-4-Hydroxyphenylpyruvate Dioxygenase (HPD) (AA 179-228) antibodyHPD 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼, Bat, Hamster, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the HPD antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the HPD antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- HPD (4-Hydroxyphenylpyruvate Dioxygenase (HPD))
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别名
- HPD
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背景
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HPD (4-hydroxyphenylpyruvate dioxygenase) is a key enzyme in the catabolism of the amino acid tyrosine. It catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate, an essential step in the tyrosine degradation pathway. By facilitating this reaction, HPD plays an important role in energy metabolism and the production of downstream metabolites. A HPD antibody is widely used in studies of amino acid metabolism and inherited metabolic disorders.
HPD is highly expressed in the liver and kidneys, organs that are central to amino acid catabolism. Its activity ensures that tyrosine is efficiently broken down, preventing the accumulation of toxic intermediates. Mutations in the HPD gene are associated with tyrosinemia type III, a rare metabolic disorder characterized by elevated levels of tyrosine in the blood and neurological symptoms. Researchers employ a HPD antibody to investigate enzyme function, tissue distribution, and the molecular basis of metabolic diseases.
Beyond its role in metabolism, HPD has clinical importance as a therapeutic target. Small-molecule inhibitors of HPD are being explored to reduce toxic metabolite accumulation in tyrosinemia type I, where blocking this enzyme helps redirect metabolic flux. Using a HPD antibody supports translational research into such therapies by enabling detailed study of enzyme expression and regulation.
NSJ Bioreagents offers a high-quality HPD antibody validated for applications such as western blot, immunohistochemistry, and immunofluorescence. Choosing a HPD antibody from NSJ Bioreagents ensures accurate detection and reproducibility in studies of amino acid metabolism, metabolic disorders, and therapeutic development. -
UniProt
- P32754
抗原
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