Presenilin 1 抗体 (AA 1-76)
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北京 101111
Quick Overview for Presenilin 1 抗体 (AA 1-76) (ABIN7869549)
抗原
See all Presenilin 1 (PSEN1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-76
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原理
- PSEN1 Antibody / Presenilin 1
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纯化方法
- Antigen affinity purified
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免疫原
- Recombinant human protein (amino acids M1-K76) was used as the immunogen for the PSEN1 antibody.
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亚型
- IgG
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anti-Presenilin 1 (PSEN1) (AA 1-160) antibody
PSEN1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 330-359), (C-Term) antibodyPSEN1 适用: 人, 小鼠 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB2257 unconjugated
anti-Presenilin 1 (PSEN1) (pSer310) antibodyKD Validated PSEN1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB4510 unconjugated Recombinant Antibody
anti-Presenilin 1 (PSEN1) (AA 4-218) antibodyPSEN1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) antibodyKD Validated PSEN1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB4515 unconjugated Recombinant Antibody
anti-Presenilin 1 (PSEN1) (Middle Region) antibodyPSEN1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 犬, 马, 兔 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 1-160) antibodyPSEN1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 300-349) antibodyPSEN1 适用: 人, 小鼠, 猴, Cow, Pig, 豚鼠, 马 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 107-156) antibodyPSEN1 适用: 人, 小鼠, 大鼠, 猴, Pig, 豚鼠, 犬, Bat, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 1-76) antibodyPSEN1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PSEN1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PSEN1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Presenilin 1 (PSEN1)
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别名
- PSEN1
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背景
- Presenilin-1 (PS-1) is a presenilin protein that in humans is encoded by the PSEN1 gene. Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
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UniProt
- P49768
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途径
- Notch Signaling, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
抗原
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