Presenilin 1 抗体 (AA 10-80)
(1 reference)-
- 抗原 See all Presenilin 1 (PSEN1) 抗体
- Presenilin 1 (PSEN1)
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抗原表位
- AA 10-80
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适用
- 小鼠
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宿主
- 小鼠
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克隆类型
- 多克隆
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标记
- This Presenilin 1 antibody is un-conjugated
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应用范围
- ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应
- 小鼠
- 预测反应
- Human,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from rat presenilin 1
- 亚型
- IgG
- Top Product
- Discover our top product PSEN1 Primary Antibody
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anti-Presenilin 1 (PSEN1) (AA 1-160) antibody
PSEN1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 330-359), (C-Term) antibodyPSEN1 适用: 人, 小鼠 WB, IHC (p), IF, FACS 宿主: 兔 Polyclonal RB2257 unconjugated
anti-Presenilin 1 (PSEN1) (AA 4-218) antibodyPSEN1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (Middle Region) antibodyPSEN1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 犬, 马, 兔 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 1-160) antibodyPSEN1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 1-100) antibody (FITC)PSEN1 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal FITC
anti-Presenilin 1 (PSEN1) (AA 1-100) antibody (Alkaline Phosphatase (AP))PSEN1 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal Alkaline Phosphatase (AP)
anti-Presenilin 1 (PSEN1) (AA 100-200) antibody (Biotin)PSEN1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal Biotin
anti-Presenilin 1 (PSEN1) (AA 100-200) antibody (PE)PSEN1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal PE
anti-Presenilin 1 (PSEN1) (AA 1-100) antibody (APC)PSEN1 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal APC
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- 应用备注
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ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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: "Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice." in: Acta biochimica et biophysica Sinica, Vol. 47, Issue 4, pp. 258-66, (2015) (PubMed).
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: "Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice." in: Acta biochimica et biophysica Sinica, Vol. 47, Issue 4, pp. 258-66, (2015) (PubMed).
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- 抗原
- Presenilin 1 (PSEN1)
- 别名
- presenilin 1 (PSEN1 产品)
- 别名
- pre1 antibody, psen antibody, zfPS1 antibody, zf-PS1 antibody, ad3 antibody, fad antibody, ps1 antibody, s182 antibody, X-PS-beta antibody, X-PS-alpha antibody, AD3 antibody, FAD antibody, PS-1 antibody, PS1 antibody, S182 antibody, Ad3h antibody, presenilin 1 antibody, presenilin 1 L homeolog antibody, psen1 antibody, PSEN1 antibody, Psen1 antibody, psen1.L antibody
- 背景
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Synonyms: Presenilin-1, PS-1, Protein S182, Psen1, Psnl1
Background: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis (By similarity).
- 基因ID
- 29192
- UniProt
- P97887
- 途径
- Notch Signaling, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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