HAP1 抗体 (AA 1-671)
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Quick Overview for HAP1 抗体 (AA 1-671) (ABIN7869522)
抗原
See all HAP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-671
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原理
- Huntingtin-associated protein 1 Antibody / HAP1
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纯化方法
- Antigen affinity purified
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免疫原
- Recombinant human protein (amino acids M1-R671) was used as the immunogen for the Huntingtin-associated protein 1 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the Huntingtin-associated protein 1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Huntingtin-associated protein 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- HAP1 (Huntingtin Associated Protein 1 (HAP1))
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别名
- Huntingtin-associated protein 1
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背景
- Huntingtin-associated protein 1 (HAP1) is a protein which in humans is encoded by the HAP1 gene. Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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UniProt
- P54257
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途径
- Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus
抗原
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