DRD5 抗体 (AA 1-477)
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Quick Overview for DRD5 抗体 (AA 1-477) (ABIN7869397)
抗原
See all DRD5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-477
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原理
- DRD5 Antibody / Dopamine receptor D5
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human DRD5 recombinant protein (Position: M1-H477) was used as the immunogen for the DRD5 antibody.
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亚型
- IgG
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anti-Dopamine Receptor D5 (DRD5) (AA 361-477) antibody
DRD5 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D5 (DRD5) (Internal Region) antibodyVerified DRD5 适用: 人 ELISA, FACS, IF 宿主: 山羊 Polyclonal unconjugated
anti-Dopamine Receptor D5 (DRD5) (2nd Extracellular Loop), (AA 199-211) antibodyDRD5 适用: 大鼠 WB, IHC, FACS, IF, LCI 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D5 (DRD5) (AA 251-350) antibodyDRD5 适用: 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D5 (DRD5) (AA 421-456), (C-Term) antibodyDRD5 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB52763 unconjugated
anti-Dopamine Receptor D5 (DRD5) (N-Term) antibodyDRD5 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D5 (DRD5) (Extracellular Domain) antibodyDRD5 适用: 人, 大鼠 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D5 (DRD5) (Cytoplasmic Domain) antibodyDRD5 适用: 人, 犬 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D5 (DRD5) (AA 19-56), (N-Term) antibodyDRD5 适用: 小鼠 WB 宿主: 兔 Polyclonal RB52770 unconjugated
anti-Dopamine Receptor D5 (DRD5) (AA 388-407), (C-Term) antibodyDRD5 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the DRD5 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the DRD5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- DRD5 (Dopamine Receptor D5 (DRD5))
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别名
- DRD5
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背景
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DRD5 antibody detects Dopamine receptor D5, encoded by the DRD5 gene on chromosome 4p15.33. DRD5 antibody is commonly used in neuroscience, pharmacology, and psychiatry research. DRD5 is a G protein-coupled receptor (GPCR) belonging to the D1-like dopamine receptor family. It couples to stimulatory G proteins (Gs), leading to activation of adenylate cyclase and increased intracellular cAMP. DRD5 plays key roles in regulating movement, reward processing, learning, and behavior. Expression is enriched in the brain, particularly in limbic regions and the hippocampus, but it is also present in peripheral tissues including kidney and vasculature.
Structurally, DRD5 is a seven-transmembrane GPCR with extracellular ligand-binding loops and intracellular domains that couple to G proteins. Compared with DRD1, DRD5 has higher affinity for dopamine and distinct distribution patterns. Post-translational modifications, including phosphorylation and palmitoylation, modulate receptor trafficking and signaling. Isoforms generated by alternative splicing may alter receptor activity in tissue-specific contexts.
Functionally, DRD5 regulates neuronal excitability, synaptic plasticity, and memory formation. In hippocampal neurons, DRD5 activation enhances long-term potentiation, a process underlying learning. In striatal circuits, it integrates with DRD1 to regulate locomotion and motor control. Outside the CNS, DRD5 influences renal sodium excretion and vascular tone, linking dopamine signaling to blood pressure regulation. Researchers use DRD5 antibody to study dopaminergic signaling, neurological disease, and receptor pharmacology.
Clinically, DRD5 has been associated with neurological and psychiatric disorders, including schizophrenia, attention deficit hyperactivity disorder, and Parkinson's disease. Polymorphisms in DRD5 contribute to variability in behavioral traits and drug responses. Studies also implicate DRD5 in hypertension due to its renal functions. Because dopamine receptors are major therapeutic targets, DRD5 is under investigation for its contribution to dopaminergic drug responses. NSJ Bioreagents supplies DRD5 antibody as a validated tool for neuroscience and pharmacology research.
Experimentally, DRD5 antibody is used in western blotting to detect the ~53 kDa receptor, in immunofluorescence microscopy to study subcellular localization, and in immunohistochemistry to map receptor distribution in brain and peripheral tissues. Co-immunoprecipitation with DRD5 antibody helps identify interacting partners and signaling complexes. -
UniProt
- P21918
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途径
- Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity
抗原
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