DRD5 抗体 (2nd Extracellular Loop)
Our Local Distributor
北京 101111
Quick Overview for DRD5 抗体 (2nd Extracellular Loop) (ABIN7043111)
抗原
See all DRD5 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- 2nd Extracellular Loop, AA 199-211
-
原理
- A Rabbit Polyclonal Antibody to D5 Dopamine Receptor
-
交叉反应
- 小鼠, 大鼠
-
交叉反应 （详细）
- Unlikely to recognize human samples.
-
预测反应
- Mouse - 12,13 amino acid residues identical
-
产品特性
- Anti-D5 Dopamine Receptor (extracellular) Antibody is directed against an epitope located at the 2nd extracellular loop of the rat D5 dopamine receptor. Anti-D5 Dopamine Receptor (extracellular) Antibody (ABIN7043111, ABIN7044234 and ABIN7044235) can be used in western blot analysis and immunohistochemical applications, and recognizes DRD5 from rat and mouse samples.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
- EEGWELEGRTENC, corresponding to amino acid residues 199-211 of rat DRD5
-
亚型
- IgG
-
-
anti-Dopamine Receptor D5 (DRD5) (AA 361-477) antibody
DRD5 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D5 (DRD5) (Internal Region) antibodyVerified DRD5 适用: 人 ELISA, FACS, IF 宿主: 山羊 Polyclonal unconjugated
anti-Dopamine Receptor D5 (DRD5) (AA 251-350) antibodyDRD5 适用: 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D5 (DRD5) (AA 421-456), (C-Term) antibodyDRD5 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB52763 unconjugated
anti-Dopamine Receptor D5 (DRD5) (N-Term) antibodyDRD5 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D5 (DRD5) (Extracellular Domain) antibodyDRD5 适用: 人, 大鼠 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D5 (DRD5) (Cytoplasmic Domain) antibodyDRD5 适用: 人, 犬 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D5 (DRD5) (AA 19-56), (N-Term) antibodyDRD5 适用: 小鼠 WB 宿主: 兔 Polyclonal RB52770 unconjugated
anti-Dopamine Receptor D5 (DRD5) (AA 388-407), (C-Term) antibodyDRD5 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D5 (DRD5) antibodyDRD5 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
WB: 1:200
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:100
IP: The optimal concentration should be determined by the user
-
说明
-
Negative Control: (ABIN7235250)
Blocking Peptide: (ABIN7235250)
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
-
浓度
- 0.8 mg/mL
-
缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
-
-
- DRD5 (Dopamine Receptor D5 (DRD5))
-
别名
- DRD5
-
背景
-
Synonyms: DRD5, D(1B) dopamine receptor
Description: The D5 dopamine receptor (D5 receptor) is one of five receptors that mediate the effects of the catecholamine neurotransmitter dopamine. Dopamine regulates a variety of functions including locomotor activity, emotion, positive reinforcement, food intake, and hormone secretion. The dopaminergic system has been extensively studied in the last thirty years mainly because its dysregulation has been linked to several neurological and neuropsychiatric diseases including Parkinson's disease and Schizophrenia.1All five dopamine receptors belong to the 7-transmembrane domain, G-protein coupled receptor (GPCR) superfamily.Historically, the five receptors have been divided into two subfamilies based on pharmacological and structural considerations: the D1-like subfamily (that includes the D1 and D5 subtypes) and the D2-like subfamily (that includes the D2-, D3- and D4 subtypes).1 The D1-like receptors are coupled to Gs-type G proteins and enhance adenylate cyclase activity while the D2-like receptors are coupled to Gi-type G proteins and inhibit adenylate cyclase activity.1The D5 receptor is widely distributed throughout the brain with the highest expression in the cerebral cortex, hippocampus and striatum. In the periphery, the D5 receptor has been localized in the adrenal cortex, kidney and intestinal tract.The exact physiological function of the D5 receptor subtype remains poorly understood. Studies with D5 receptor knockout mice have shown no overt alterations in locomotor or cognitive functions. However, knockout mice do develop severe hypertension suggesting a role of the D5 receptor in the modulation of neuronal pathways regulating blood pressure responses.2,3
-
基因ID
- 25195
-
NCBI登录号
- NM_000798
-
UniProt
- P25115
-
途径
- Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity
抗原
-
