APC 抗体 (AA 1-433)
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北京 101111
Quick Overview for APC 抗体 (AA 1-433) (ABIN7869356)
抗原
See all APC 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 1-433
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原理
- Adenomatous polyposis coli Antibody / APC (azide and preservative free)
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纯化方法
- Protein G affinity chromatography
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免疫原
- A recombinant human partial protein (amino acids 1-433) was used as the immunogen for the Adenomatous polyposis coli antibody.
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亚型
- IgG1, kappa
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anti-Adenomatous Polyposis Coli (APC) (AA 2636-2845) antibody
APC 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Adenomatous Polyposis Coli (APC) (AA 2544-2843) antibodyAPC 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adenomatous Polyposis Coli (APC) (AA 2634-2842) antibodyAPC 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Adenomatous Polyposis Coli (APC) (AA 2744-2843) antibodyAPC 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 3E2 unconjugated
anti-Adenomatous Polyposis Coli (APC) (pSer2054) antibodyAPC 适用: 人, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Adenomatous Polyposis Coli (APC) (C-Term) antibodyAPC 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Adenomatous Polyposis Coli (APC) (AA 2751-2843) antibodyAPC 适用: 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Adenomatous Polyposis Coli (APC) (AA 1-2843) antibodyAPC 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Adenomatous Polyposis Coli (APC) (AA 1-50) antibodyAPC 适用: 人 IHC 宿主: 兔 Polyclonal unconjugated
anti-Adenomatous Polyposis Coli (APC) antibodyAPC 适用: 人 WB, IHC, ELISA 宿主: 兔 Monoclonal 5F2 unconjugated Recombinant Antibody
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应用备注
- Optimal dilution of the Adenomatous polyposis coli antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the Adenomatous polyposis coli antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- APC (Adenomatous Polyposis Coli (APC))
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别名
- Adenomatous polyposis coli
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背景
- The adenomatous polyposis syndromes, familial adenomatous polyposis (FAP) and Gardner's syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. The cloning of the APC gene revealed a ubiquitously expressed protein, 2,843 amino acids in length, which is frequently mutated in patients suffering from FAP and GS. APC has been found to be associated with structural components of intracellular junctions. Functions as a tumor suppressor, promoting rapid degradation of CTNNB1 and is a negative regulator of Wnt signaling. Also plays a role in HGF-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
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UniProt
- P25054
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途径
- WNT signaling, Stem Cell Maintenance, Cell-Cell Junction Organization
抗原
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