MAP3K2 抗体 (AA 1-364)
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Quick Overview for MAP3K2 抗体 (AA 1-364) (ABIN7869256)
抗原
See all MAP3K2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-364
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原理
- MEKK2 Antibody
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纯化方法
- Affinity purified
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免疫原
- A human recombinant partial protein (amino acids M1-Q364) was used as the immunogen for the MEKK2 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the MEKK2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the MEKK2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MAP3K2 (Mitogen-Activated Protein Kinase Kinase Kinase 2 (MAP3K2))
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别名
- MEKK2
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背景
- MAP3K2, mitogen-activated protein kinase kinase kinase 2, also known as MEKK2, belongs to the mitogen-activated protein kinase (MAPK) kinase kinase gene family, which is involved in regulating multiple MAPK signaling pathways. Endogenous MAP3K2 localized mainly to the cytosol of unstimulated HeLa cells and rat fibroblasts. The MAP3K2 gene is mapped to chromosome 2 by the International Radiation Hybrid Mapping Consortium. MAP3K2 is a major upstream activator of the JNK, MAPK cascade. MAP3K2 was identifies as 1 of 6 kinases that regulate different steps of the caveolar cycle. Silencing of MAP3K2 strongly reduced kiss-and-run dynamics, leading to an accumulation of caveolar structures at the cell surface without affecting caveolae coat assembly or clustering.
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UniProt
- Q9Y2U5
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途径
- MAPK Pathway
抗原
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