Nkx2-2 抗体 (AA 1-269)
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Quick Overview for Nkx2-2 抗体 (AA 1-269) (ABIN7869010)
抗原
See all Nkx2-2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-269
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原理
- Zebrafish Nkx2.2a Antibody / Nkx2.2
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纯化方法
- Antigen affinity chromatography
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免疫原
- E. coli-derived zebrafish Nkx2.2a recombinant protein (amino acids M1-W269) was used as the immunogen for the Zebrafish Nkx2.2a antibody.
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亚型
- Ig Fraction
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anti-NK2 Homeobox 2 (Nkx2-2) (AA 1-119) antibody
Nkx2-2 适用: 人 IHC 宿主: 小鼠 Monoclonal NX2-1523 unconjugated
anti-NK2 Homeobox 2 (Nkx2-2) (AA 1-119) antibodyNkx2-2 适用: 人 IHC, IF, FACS 宿主: 小鼠 Monoclonal NX2-1524 unconjugated
anti-NK2 Homeobox 2 (Nkx2-2) antibodyNkx2-2 适用: 人, 小鼠, 大鼠, 小鸡 IHC, IF, FACS 宿主: 小鼠 Monoclonal NX2-294 unconjugated
anti-NK2 Homeobox 2 (Nkx2-2) antibodyNkx2-2 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 3E4 unconjugated
anti-NK2 Homeobox 2 (Nkx2-2) (N-Term) antibodyNkx2-2 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 豚鼠, 马, 绵羊 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-NK2 Homeobox 2 (Nkx2-2) antibodyNkx2-2 适用: 人, 小鼠, 大鼠, 小鸡 IHC, WB 宿主: 小鼠 Monoclonal rNX2-294 unconjugated Recombinant Antibody
anti-NK2 Homeobox 2 (Nkx2-2) antibodyNkx2-2 适用: 人 FACS, WB, ICC 宿主: 兔 Monoclonal 24GB715 unconjugated Recombinant Antibody
anti-NK2 Homeobox 2 (Nkx2-2) (AA 1-119) antibodyNkx2-2 适用: 人 IHC 宿主: 小鼠 Monoclonal rNX2-1523 unconjugated Recombinant Antibody
anti-NK2 Homeobox 2 (Nkx2-2) (AA 1-119) antibodyNkx2-2 适用: 人 IHC 宿主: 兔 Monoclonal NX2-2198R unconjugated Recombinant Antibody
anti-NK2 Homeobox 2 (Nkx2-2) antibodyNkx2-2 适用: 人 IHC 宿主: 兔 Monoclonal NX2-1422R unconjugated Recombinant Antibody
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应用备注
- Optimal dilution of the Zebrafish Nkx2.2a antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Nkx2.2a antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))
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别名
- Nkx2.2a
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背景
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Nkx2.2a is a homeobox transcription factor that plays a critical role in the development of the central nervous system and pancreas in zebrafish. It belongs to the NK class of homeodomain proteins and functions by regulating gene expression involved in cell fate determination and patterning during embryogenesis.
Zebrafish Nkx2.2a is one of two paralogs, the other being Nkx2.2b, resulting from a genome duplication event in teleosts. Nkx2.2a is considered a functional ortholog of the human NKX2 dash 2 gene. Both proteins are highly conserved and share similar developmental roles, particularly in the specification of ventral neural progenitors and in endocrine pancreas formation.
In zebrafish embryos, Nkx2.2a is expressed in the ventral neural tube, including the regions that give rise to motor neurons, oligodendrocyte precursors, and serotonergic neurons. It acts downstream of sonic hedgehog signaling and is essential for defining the identity of specific neuronal subtypes. Nkx2.2a also contributes to the early development of the pancreas, where it helps regulate differentiation of insulin producing beta cells and other endocrine cell types.
Loss of Nkx2.2a function in zebrafish leads to defects in neuronal patterning and impaired endocrine pancreas development, mirroring the phenotypes observed in mammalian systems. Due to its conservation with the human NKX2 dash 2 gene and its involvement in key developmental processes, zebrafish Nkx2.2a is widely used as a model to study neurogenesis, pancreas biology, and transcriptional regulation in vertebrates.
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UniProt
- Q90481
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途径
- Dopaminergic Neurogenesis
抗原
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