MYD88 抗体 (AA 1-266)
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Quick Overview for MYD88 抗体 (AA 1-266) (ABIN7869005)
抗原
See all MYD88 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-266
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原理
- Zebrafish Myd88 Antibody
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纯化方法
- Antigen affinity chromatography
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免疫原
- E. coli-derived zebrafish Myd88 recombinant protein (amino acids M1-K266) was used as the immunogen for the Zebrafish Myd88 antibody.
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亚型
- Ig Fraction
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anti-Myeloid Differentiation Primary Response Gene (88) (MYD88) (AA 44-264) antibody
MYD88 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC, FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Myeloid Differentiation Primary Response Gene (88) (MYD88) (AA 201-296) antibodyMYD88 适用: 人, 小鼠, 大鼠, 小鸡 WB, ELISA, IP, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Myeloid Differentiation Primary Response Gene (88) (MYD88) (AA 32-265) antibodyMYD88 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Myeloid Differentiation Primary Response Gene (88) (MYD88) (Internal Region) antibodyVerified MYD88 适用: 人 WB, IHC, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Myeloid Differentiation Primary Response Gene (88) (MYD88) (AA 1-296) antibodyMYD88 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Myeloid Differentiation Primary Response Gene (88) (MYD88) (AA 136-164) antibodyMYD88 适用: 人, 小鼠 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Myeloid Differentiation Primary Response Gene (88) (MYD88) (AA 1-296) antibodyMYD88 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Myeloid Differentiation Primary Response Gene (88) (MYD88) (AA 1-296) antibodyMYD88 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Myeloid Differentiation Primary Response Gene (88) (MYD88) (AA 60-309) antibodyMYD88 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Myeloid Differentiation Primary Response Gene (88) (MYD88) antibodyKO Validated MYD88 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
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应用备注
- Optimal dilution of the Zebrafish Myd88 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Myd88 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))
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别名
- Myd88
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背景
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Myd88, or myeloid differentiation primary response protein 88, is an essential adaptor molecule in the innate immune system. In zebrafish, Myd88 mediates signal transduction from toll like receptors and interleukin one receptors, leading to activation of downstream inflammatory pathways that are critical for host defense.
Myd88 contains a death domain and a toll interleukin one receptor domain, which allow it to interact with both membrane bound receptors and cytoplasmic signaling proteins. Upon stimulation by pathogen associated molecular patterns such as bacterial lipopolysaccharide or viral RNA, toll like receptors recruit Myd88 to initiate signaling cascades that activate nuclear factor kappa B and mitogen activated protein kinases. This results in the production of proinflammatory cytokines and chemokines.
In zebrafish, Myd88 is maternally deposited and expressed throughout development, with increased expression in immune tissues such as the kidney and intestine. It plays a vital role in early immune responses to infection and has been extensively used in zebrafish models of inflammation, pathogen challenge, and immune signaling.
Loss of Myd88 function in zebrafish leads to impaired cytokine production and increased susceptibility to microbial infections, making it a valuable target for studies of innate immunity and inflammation. Due to its conservation across vertebrate species, zebrafish Myd88 is a widely used model for dissecting toll like receptor signaling and for testing immunomodulatory drugs.
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UniProt
- Q5XJ85
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途径
- NF-kappaB Signaling, TLR signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades
抗原
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