Recombinant TIM3 抗体 (AA 1-200)
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北京 101111
Quick Overview for Recombinant TIM3 抗体 (AA 1-200) (ABIN7868512)
抗原
See all TIM3 (TIM 3) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 1-200
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原理
- TIM-3 Antibody / HAVCR2 (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant fragment of human TIM3 protein (within amino acids 1-200) was used as the immunogen for the TIM-3 antibody.
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亚型
- IgG, kappa
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anti-Hepatitis A Virus Cellular Receptor 2 (TIM 3) (Internal Region) antibody
Verified TIM 3 适用: 人 WB, FACS, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 22-201) antibodyTIM 3 适用: 人 WB, FACS, IHC, ICC, IF (p) 宿主: 兔 Monoclonal BLR033F unconjugated Recombinant Antibody
anti-Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 22-202) antibodyTIM 3 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal TIM3-3113 unconjugated
anti-Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 167-194) antibodyTIM 3 适用: 人 WB 宿主: 兔 Polyclonal RB41963 unconjugated
anti-Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 22-202) antibodyTIM 3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 224-301) antibodyTIM 3 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 2A7A6 unconjugated
anti-Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 22-202) antibodyTIM 3 适用: 人 FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 7C8A7 unconjugated
anti-Hepatitis A Virus Cellular Receptor 2 (TIM 3) antibodyTIM 3 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Hepatitis A Virus Cellular Receptor 2 (TIM 3) antibodyTIM 3 适用: 人 IHC 宿主: 兔 Monoclonal 366R unconjugated Recombinant Antibody
anti-Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 22-202) antibodyTIM 3 适用: 人 WB, IHC, ICC, IP 宿主: 小鼠 Monoclonal C1 unconjugated
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应用备注
- Optimal dilution of the TIM-3 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the TIM-3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))
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别名
- TIM-3
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背景
- TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cells (CD4+ Th1 and CD8+ Tc1) but not on helper T cells (CD4+ Th2 and CD8+ Tc2). In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and pro-apoptotic signaling. TIM-3 functions as a negative regulator of Th1 cell activity. Its blockade results in increased IFN-gamma production, Th1 cell proliferation and cytotoxicity, regulatory T cell development, and increases in macrophage and neutrophil infiltration into sites of inflammation.
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UniProt
- Q8TDQ0
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途径
- Regulation of Lipid Metabolism by PPARalpha, Cancer Immune Checkpoints
抗原
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