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MSH2 抗体

This 小鼠 单克隆 antibody specifically detects MSH2 in IHC. It exhibits reactivity toward 人.
产品编号 ABIN7865693
发货至: 中国
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中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for MSH2 抗体 (ABIN7865693)

抗原

See all MSH2 抗体
MSH2 (Mismatch Repair Protein 2 (MSH2))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This MSH2 antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC)

克隆位点

IHC410
  • 原理

    anti-MSH2 mouse monoclonal, IHC410, purified

    纯化方法

    affinity chromatography

    免疫原

    Recombinant Human MSH2

    亚型

    IgG2b
  • 应用备注

    Optional[ICC/IF_dilution]: 1:50-1:200 (microwave treatment recommended)

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Tris pH 7.3-7.7 with 1 % BSA and 0.09 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    store at 2 - 8 °C
  • 抗原

    MSH2 (Mismatch Repair Protein 2 (MSH2))

    别名

    MSH2

    背景

    MutS Homolog 2 (MSH2) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, and mutations in this gene are correlated with the development of sporadic colorectal carcinoma. Expression levels of MSH2 are abnormally low in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MSH2 is optimized when paired in an IHC panel with antibodies against MSH6, MLH1, and PMS2. Reports have shown Anti-MSH2 to be useful in the detection of the protein in a number of normal and neoplastic tissues, and for identifying a loss of MSH2 in tumours that are microsatellite-unstable.

    途径

    DNA Damage Repair, Production of Molecular Mediator of Immune Response
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