MSH2 抗体
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北京 101111
Quick Overview for MSH2 抗体 (ABIN7865693)
抗原
See all MSH2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- anti-MSH2 mouse monoclonal, IHC410, purified
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纯化方法
- affinity chromatography
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免疫原
- Recombinant Human MSH2
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亚型
- IgG2b
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应用备注
- Optional[ICC/IF_dilution]: 1:50-1:200 (microwave treatment recommended)
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Tris pH 7.3-7.7 with 1 % BSA and 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- store at 2 - 8 °C
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- MSH2 (Mismatch Repair Protein 2 (MSH2))
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别名
- MSH2
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背景
- MutS Homolog 2 (MSH2) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, and mutations in this gene are correlated with the development of sporadic colorectal carcinoma. Expression levels of MSH2 are abnormally low in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MSH2 is optimized when paired in an IHC panel with antibodies against MSH6, MLH1, and PMS2. Reports have shown Anti-MSH2 to be useful in the detection of the protein in a number of normal and neoplastic tissues, and for identifying a loss of MSH2 in tumours that are microsatellite-unstable.
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途径
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
抗原
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