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Integrin beta 3 抗体

This 小鼠 单克隆 antibody specifically detects Integrin beta 3 in IHC, FACS, IF 和 ICC. It exhibits reactivity toward 人.
产品编号 ABIN7865663
发货至: 中国
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中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for Integrin beta 3 抗体 (ABIN7865663)

抗原

See all Integrin beta 3 (ITGB3) 抗体
Integrin beta 3 (ITGB3)

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This Integrin beta 3 antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC)

克隆位点

EBS-CD-034
  • 原理

    anti-CD61 mouse monoclonal, EBS-CD-034, purified

    纯化方法

    affinity chromatography

    免疫原

    stimulated human PBMC's

    亚型

    IgM kappa
  • 应用备注

    ICC/IF_dilution: 1:100-1:200 (0.5-1.0 μg/mL)

    FACS_dilution: 0.5-1.0 μg/million cells in 0.1 ml

    IHC-frozen_dilution: 1:50-1:100 (1-2 μg/mL)

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    100 μg/mL

    缓冲液

    PBS with 0.02 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    store at 2 - 8 °C
  • 抗原

    Integrin beta 3 (ITGB3)

    别名

    CD61

    背景

    EBS-CD-034 reacts with a complex of CD41 and CD61, i.e. alpha IIb integrin and the integrin beta chain. The MW of the GPIIIa is 105 kDa unreduced and 90 kDa reduced. The integrin beta 3 chain can also form a complex called the vitronectin receptor with integrin alpha V: the CD51/CD61 complex. Ligands are fibrinogen, fibronectin, von Willebrand factor, vitronectin and thrombospondin. Residues 237-248 of GPIIIa or CD61 are critical in adhesive protein binding. The CD51/CD61 complex is also found on endothelial cells, some B-cells, monocytes/macrophages and tumor cells. Positive control: U937, KG1a, HEL cells, human platelets in lymph nodes or tonsils.

    途径

    Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex
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