WTAP 抗体
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北京 101111
Quick Overview for WTAP 抗体 (ABIN7865027)
抗原
See all WTAP 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- WTAP Antibody
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特异性
- Wilms tumor (WT) is an embryonal malignancy of the kidney that affects 1 in 10,000 infants and is observed in both sporadic and inherited forms. The Wilms tumor protein (WT1) binds the DNA sequence GCGGGGGCG, a recognition element common to the early growth response (Egr) family of Zn2+ finger transcriptional activators, and functions as a transcriptional repressor. WTAP (wilms tumor 1-associating protein) is a ubiquitously expressed nuclear protein that interacts with WT1 and may be involved in regulating mRNA splicing. WTAP is found in nuclear speckles, where it regulates the G2/M cell cycle transition by binding to the 3' UTR of cyclin A2, thus enhancing its stability. Additionally, WTAP inhibits expression of WT1 target genes and is able to impair the ability of WT1 to bind DNA. Two isoforms of WTAP exist due to alternative splicing events.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant full-length human WTAP protein
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亚型
- IgG2b, kappa
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anti-Wilms Tumor 1 Associated Protein (WTAP) (AA 91-201) antibody
WTAP 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 6B6B8 unconjugated
anti-Wilms Tumor 1 Associated Protein (WTAP) (AA 91-201) antibodyWTAP 适用: 人, 猴 WB, ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 6B6B6 unconjugated
anti-Wilms Tumor 1 Associated Protein (WTAP) (AA 70-151) antibodyWTAP 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1B11 unconjugated
anti-Wilms Tumor 1 Associated Protein (WTAP) (C-Term) antibodyWTAP 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Wilms Tumor 1 Associated Protein (WTAP) (AA 346-396) antibodyWTAP 适用: 人 IHC, IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Wilms Tumor 1 Associated Protein (WTAP) (AA 1-151) antibodyWTAP 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Wilms Tumor 1 Associated Protein (WTAP) (AA 1-396) antibodyWTAP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Wilms Tumor 1 Associated Protein (WTAP) (Center) antibodyWTAP 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Wilms Tumor 1 Associated Protein (WTAP) antibodyKD Validated WTAP 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 25GB4070 unconjugated
anti-Wilms Tumor 1 Associated Protein (WTAP) (AA 1-150) antibodyWTAP 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- WTAP (Wilms Tumor 1 Associated Protein (WTAP))
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别名
- WTAP
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背景
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Female-lethal(2)D homolog, hFL(2)D, PNAS132, Pre-mRNA-splicing regulator WTAP, Putative pre mRNA splicing regulator female lethal(2D), Wilms' tumour 1-associating protein, WT1 associated protein
Ubiquitous expression.
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分子量
- 44.2kDa
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基因ID
- 9589, 446091
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UniProt
- Q15007
抗原
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