PRMT6 抗体
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北京 101111
Quick Overview for PRMT6 抗体 (ABIN7863271)
抗原
See all PRMT6 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- PRMT6 Antibody
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特异性
- A class of proteins termed type 1 protein arginine N-methyltransferase (PRMT) enzymes contribute to posttranslational modification of RNA-binding proteins, but differ in substrate specificities, oligomerization properties and subcellular localization. PRMTs contain an S-adenosylmethione motif which functions to add one or two methyl groups to guanidino nitrogens of arginine (R) side chains. PRMT6, also known as HRMT1L6, is a nuclear protein belonging to the PRMT family and is predominantly expressed in testis and kidney. It is known to methylate Histones H3, H4 and H2A. PRMT6 is the major dimethyltransferase for Histone H3 and specifically methylates Histone H3 at R2. Methylation at Histone H3 R2 acts to inhibit Histone H3 K4 trimethylation and ultimately leads to the transcriptional repression of genes that are activated by Histone H3 K4 trimethylation. In addition, PRMT6 methylates HIV TAT, possibly functioning as a form of cellular innate immunity to restrict levels of HIV replication.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant full-length human PRMT6 protein
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亚型
- IgG2b
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anti-Protein Arginine Methyltransferase 6 (PRMT6) (AA 1-316) antibody
PRMT6 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3C3 unconjugated
anti-Protein Arginine Methyltransferase 6 (PRMT6) antibodyKD Validated PRMT6 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB1585 unconjugated Recombinant Antibody
anti-Protein Arginine Methyltransferase 6 (PRMT6) (AA 19-48) antibodyPRMT6 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 6 (PRMT6) (AA 119-375) antibodyPRMT6 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 6 (PRMT6) (AA 1-316) antibodyPRMT6 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 6 (PRMT6) (AA 1-316) antibodyPRMT6 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 6 (PRMT6) (AA 23-43) antibodyPRMT6 适用: 人, 小鼠, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 6 (PRMT6) (C-Term) antibodyPRMT6 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 6 (PRMT6) (AA 301-375) antibodyPRMT6 适用: 人, 小鼠, 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Protein Arginine Methyltransferase 6 (PRMT6) (N-Term) antibodyPRMT6 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- PRMT6 (Protein Arginine Methyltransferase 6 (PRMT6))
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别名
- PRMT6
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背景
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Chromobox protein homolog 7, Heterogeneous nuclear ribonucleoprotein methyltransferase like protein 6, Histone-arginine N-methyltransferase PRMT6, HMT1 hnRNP methyltransferase like 6., HRMT1L6
HeLa, MCF7 or HepG2 cells.
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分子量
- 42kDa
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基因ID
- 55170, 26006
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UniProt
- Q96LA8
抗原
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