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PRMT6 抗体 (AA 119-375)

PRMT6 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7165075
发货至: 中国
  • 抗原 See all PRMT6 抗体
    PRMT6 (Protein Arginine Methyltransferase 6 (PRMT6))
    抗原表位
    • 6
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 119-375
    适用
    • 45
    • 17
    • 8
    • 7
    • 6
    • 5
    • 4
    • 3
    宿主
    • 34
    • 10
    • 1
    克隆类型
    • 35
    • 10
    多克隆
    标记
    • 34
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PRMT6 antibody is un-conjugated
    应用范围
    • 27
    • 12
    • 12
    • 9
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Protein arginine N-methyltransferase 6 protein (119-375AA)
    亚型
    IgG
  • 应用备注
    Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    PRMT6 (Protein Arginine Methyltransferase 6 (PRMT6))
    别名
    PRMT6 (PRMT6 产品)
    别名
    CG9927 antibody, DART6 antibody, Dmel\\CG9927 antibody, PRMT6 antibody, HRMT1L6 antibody, ARABIDOPSIS THALIANA PROTEIN ARGININE METHYLTRANSFERASE 6 antibody, ATPRMT6 antibody, protein arginine methyltransferase 6 antibody, DKFZp459B1431 antibody, Hrmt1l6 antibody, hrmt1l6 antibody, hrmt6 antibody, im:6908706 antibody, AW124876 antibody, BB233495 antibody, Arginine methyltransferase 6 antibody, protein arginine methyltransferase 6 antibody, protein arginine methyltransferase 6 S homeolog antibody, arginine N-methyltransferase, type I antibody, protein arginine N-methyltransferase 6 antibody, Art6 antibody, PRMT6 antibody, prmt6.S antibody, prmt6 antibody, Prmt6 antibody
    背景

    Background: Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 \\\'Arg-2\\\' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 \\\'Lys-4\\\' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 \\\'Arg-3\\\' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC).

    Aliases: ANM6_HUMAN antibody, Chromobox protein homolog 7 antibody, FLJ10559 antibody, FLJ51477 antibody, Heterogeneous nuclear ribonucleoprotein methyltransferase like protein 6 antibody, Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 antibody, Histone-arginine N-methyltransferase PRMT6 antibody, HMT1 hnRNP methyltransferase like 6. antibody, HRMT1L6 antibody, OTTHUMP00000012633 antibody, PRMT 6 antibody, prmt6 antibody, Protein arginine methyltransferase 6 antibody, Protein arginine N methyltransferase 6 antibody, Protein arginine N-methyltransferase 6 antibody

    UniProt
    Q96LA8
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