LRP1 抗体
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北京 101111
Quick Overview for LRP1 抗体 (ABIN7861641)
抗原
See all LRP1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- CD91 / LDL Receptor Related Protein 1 (LRP1) Antibody
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特异性
- Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LEP1 (low density lipoprotein related protein), megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and apoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. LRP1, also designated LRP and ±-2-Macroglobulin receptor, is an endocytic receptor that mediates the uptake of at least 15 ligands, including ±-2-Macroglobulin and apoE. LRP1 is cleaved into a membrane subunit and an extracellular subunit, which remain non-covalently associated. Proper folding and trafficking of LRP1 is facilitated by the receptor-associated protein (RAP), a molecular chaperone. The uptake of all known ligands through LRP1 can be blocked by RAP, which induces a conformational change in the receptor that renders it unable to bind ligands. LRP1, which is expressed in brain, liver and lung, is also implicated in Alzheimer s disease (AD), as the human LRP gene localizes to a potential AD locus on chromosome 12.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment of human LRP1 protein (exact sequence is proprietary)
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亚型
- IgG1, kappa
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anti-Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) (AA 20-270) antibody
LRP1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) (AA 20-155) antibodyLRP1 适用: 人 IHC, FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 3F12E2 unconjugated
anti-Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) (AA 4451-4545) antibodyLRP1 适用: 人, 小鼠 FACS, ELISA, IHC (p), IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) (AA 4441-4544) antibodyLRP1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) (AA 1-292) antibodyLRP1 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) antibodyLRP1 适用: 人 WB, IHC, FACS, ELISA, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal A2Mralpha-2 unconjugated
anti-Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) (C-Term) antibodyLRP1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) antibodyKD Validated LRP1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB2130 unconjugated Recombinant Antibody
anti-Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) antibodyKD Validated LRP1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB4945 unconjugated Recombinant Antibody
anti-Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) (pSer4523) antibodyLRP1 适用: 人, 大鼠 FACS, ELISA, IHC (p), IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))
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别名
- CD91
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背景
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A2MR, Alpha 2 macroglobulin receptor, APOER, Apolipoprotein E receptor, IGFBP3R, Low-density lipoprotein receptor-related protein 1 intracellular domain, LRP-1, LRP-515, LRP-85, Lrp1, LRP1 protein, Prolow density lipoprotein receptor related protein 1, TbetaRV/LRP1/IGFBP3 receptor, TGFBR5, Type V tgf beta receptor
brain or lung.|Human liver
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分子量
- 85/515/600kDa
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基因ID
- 4035, 162757
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UniProt
- Q07954
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途径
- Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling
抗原
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