LAG3 抗体 (AA 300-500)
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北京 101111
Quick Overview for LAG3 抗体 (AA 300-500) (ABIN7859812)
抗原
See all LAG3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 300-500
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原理
- Lymphocyte Activation Gene 3 (LAG-3) (Negative Checkpoint Regulator) Antibody
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特异性
- LAG-3 (also called CD223) is a high affinity MHC class II ligand present on the surface of CD4+CD8+ T cells and NK cell, with shared homology in structure to CD4 Molecules. It has a glutamic acid-proline (EP) repetitive sequence found in other functionally distinct mammalian, parasitic, and bacterial proteins that may influence a conserved biological function. LAG-3+CD4+CD8+ T cells can associate with the T cell receptor (TCR) and downregulate TCR signaling in vitro. LAG-3 inhibits CD4-dependent T cell function via its cytoplasmic domain. LAG-3 Lys-468 within a conserved KIEELE motif is essential for interaction with downstream signaling molecules. Furthermore, as a checkpoint inhibitor target, it may be superior to CTLA-4 and PD-1 since both antibodies only activate effector T-cells, whereas an antagonist LAG-3 antibody can both activate T effector cells (by downregulating the LAG-3 inhibiting signal into pre-activated LAG-3+ cells) and inhibit induced (i.e. antigen-specific) Treg suppressive activity.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (around aa300-500) of human LAG3 protein (exact sequence is proprietary)
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亚型
- IgG1, kappa
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anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 500-525) antibody
LAG3 适用: 人 WB, IHC, ICC, FACS, IP, IF (p), mIF 宿主: 兔 Monoclonal BLR027F unconjugated Recombinant Antibody
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 103-132) antibodyLAG3 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21775 unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 23-450) antibodyLAG3 适用: 人 WB, IHC, ICC, FACS, IP, IF (p) 宿主: 兔 Monoclonal BLR028F unconjugated Recombinant Antibody
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 66-199) antibodyLAG3 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 4H6A3 unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 103-132) antibodyLAG3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 29-450) antibodyLAG3 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 8B12E10 unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 1-360) antibodyLAG3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 250-300) antibodyLAG3 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Monoclonal BLR261L unconjugated Recombinant Antibody
anti-Lymphocyte-Activation Gene 3 (LAG3) (AA 201-300) antibodyLAG3 适用: 人, 小鼠 WB, ELISA, ICC, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte-Activation Gene 3 (LAG3) antibodyLAG3 适用: 小鼠 FACS, IP, BP 宿主: 兔 Chimeric C9B7W unconjugated Recombinant Antibody
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- LAG3 (Lymphocyte-Activation Gene 3 (LAG3))
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别名
- Lymphocyte Activation Gene 3
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背景
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CD223, FDC protein, LAG-3
Human tonsil or Hodgkin s lymphoma (IHC-P).
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分子量
- 70kDa
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基因ID
- 3902, 409523
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
抗原
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