BRCA2 抗体 (AA 200-500)
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北京 101111
Quick Overview for BRCA2 抗体 (AA 200-500) (ABIN7859523)
抗原
See all BRCA2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 200-500
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原理
- BRCA2 (Breast Marker) Antibody
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特异性
- In 1990, a breast cancer susceptibility gene designated BRCA1 was localized to chromosome 17q. Mutations within this gene are believed to account for approximately 45 % of families with high incidence of breast cancer and at least 80 % of families with increased incidence of both early-onset breast cancer and ovarian cancer. A second breast cancer susceptibility gene, BRCA2 (breast cancer 2, early onset), located on chromosome 13q13.1, also confers a high incidence of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer. Both BRCA1 and BRCA2 play a role in the maintainance of genome stability, particularly in the homologous recombination pathway for double-strand DNA repair. BRCA2 is regarded as a tumor suppressor gene, tumors with BRCA2 mutations exhibit loss of heterozygosity (LOH) of the wildtype allele. The protein encoded by the BRCA2 gene contains multiple copies of a 70 amino acid motif called the BRC motif. These motifs effect binding to the Rad51 recombinase, which operates in DNA repair.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (around aa 200-500) of human BRCA2 protein (exact sequence is proprietary)
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亚型
- IgG1, kappa
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anti-Breast Cancer 2, Early Onset (BRCA2) (AA 21-130) antibody
BRCA2 适用: 人 WB, ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) antibodyBRCA2 适用: 人, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) (AA 2990-3232) antibodyBRCA2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) (AA 3319-3418) antibodyBRCA2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D12 unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) (AA 1-300) antibodyBRCA2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) (AA 2913-3151) antibodyBRCA2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) (AA 251-495) antibodyBRCA2 适用: 人 WB 宿主: 小鼠 Monoclonal 1643CT739-91-87 unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) (AA 2308-2537) antibodyBRCA2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) (AA 2737-2874) antibodyBRCA2 适用: 斑马鱼 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Breast Cancer 2, Early Onset (BRCA2) (C-Term) antibodyBRCA2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- BRCA2 (Breast Cancer 2, Early Onset (BRCA2))
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别名
- BRCA2
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背景
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BRCA1/BRCA2 containing complex subunit 2, BRCA2, DNA repair associated, BRCC2, Breast and ovarian cancer susceptibility gene early onset, breast and ovarian cancer susceptibility protein 2, Breast cancer 2 early onset, Breast Cancer 2 tumor suppressor, BROVCA2, FACD, FAD1, FANCB, FANCD, FANCD1, Fanconi anemia complementation group D1, GLM3, mutant BRCA2, PNCA2, XRCC11
A431 or HeLa cells. Human breast|lung|ovary or spleen.|thymus
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分子量
- 390kDa
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基因ID
- 675, 34012
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途径
- DNA Damage Repair, M Phase, Maintenance of Protein Location
抗原
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