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BRCA2 抗体 (AA 251-495)

BRCA2 适用: 人 WB 宿主: 小鼠 Monoclonal 1643CT739-91-87 unconjugated
产品编号 ABIN6242777
发货至: 中国
  • 抗原 See all BRCA2 抗体
    BRCA2 (Breast Cancer 2, Early Onset (BRCA2))
    抗原表位
    • 15
    • 12
    • 7
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 251-495
    适用
    • 56
    • 23
    • 20
    • 4
    • 2
    • 1
    • 1
    • 1
    宿主
    • 56
    • 6
    小鼠
    克隆类型
    • 55
    • 7
    单克隆
    标记
    • 31
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This BRCA2 antibody is un-conjugated
    应用范围
    • 37
    • 17
    • 13
    • 13
    • 9
    • 6
    • 5
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB)
    纯化方法
    This antibody is purified through a protein G column, followed by dialysis against PBS.
    免疫原
    This BRCA2 antibody is generated from a mouse immunized with a recombinant protein between 251-495 amino acids from human BRCA2.
    克隆位点
    1643CT739-91-87
    亚型
    IgG1 kappa
    Top Product
    Discover our top product BRCA2 Primary Antibody
  • 应用备注
    WB: 1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • 抗原
    BRCA2 (Breast Cancer 2, Early Onset (BRCA2))
    别名
    BRCA2 (BRCA2 产品)
    别名
    BRCC2 antibody, BROVCA2 antibody, FACD antibody, FAD antibody, FAD1 antibody, FANCB antibody, FANCD antibody, FANCD1 antibody, GLM3 antibody, PNCA2 antibody, 30169 antibody, BcDNA:SD25109 antibody, CG13583 antibody, CG13584 antibody, CG30169 antibody, Dmel\\CG30169 antibody, brca2 antibody, dmbrca2 antibody, fancd1 antibody, BRCA2 antibody, brcc2 antibody, brovca2 antibody, facd antibody, fad antibody, fad1 antibody, fancb antibody, AI256696 antibody, AW045498 antibody, Fancd1 antibody, RAB163 antibody, BRCA2, DNA repair associated antibody, Breast cancer 2, early onset homolog antibody, breast cancer 2, early onset antibody, BRCA2 antibody, Brca2 antibody, brca2 antibody, LOC584780 antibody
    背景
    Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks, together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and DSS1, and is required to prevent R-loop- associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:< a href="http://www.uniprot.org/citations/24896180" target="_blank">24896180).
    分子量
    384202
    UniProt
    P51587
    途径
    DNA Damage Repair, M Phase, Maintenance of Protein Location
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