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TCF7 抗体 (AA 200-400)

The 小鼠 单克隆 anti-TCF7 antibody (Clone TCF7-7631) (ABIN7859521) specifically detects TCF7 in IHC. The antibody is reactive with 人 samples.
产品编号 ABIN7859521
发货至: 中国
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Quick Overview for TCF7 抗体 (AA 200-400) (ABIN7859521)

抗原

See all TCF7 抗体
TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7))

适用

  • 62
  • 41
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  • 7
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  • 1
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宿主

  • 54
  • 11
  • 1
小鼠

克隆类型

  • 52
  • 14
单克隆

标记

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  • 2
  • 2
  • 2
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This TCF7 antibody is un-conjugated

应用范围

  • 45
  • 21
  • 18
  • 9
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Immunohistochemistry (IHC)

克隆位点

TCF7-7631
  • 抗原表位

    • 10
    • 8
    • 5
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    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    • 1
    • 1
    • 1
    • 1
    AA 200-400

    原理

    TCF7 Antibody

    特异性

    Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes.

    纯化方法

    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

    免疫原

    Recombinant fragment (around aa200-400) of human TCF7 protein (exact sequence is proprietary)

    亚型

    IgG2, kappa
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    Prepared in 10  mM PBS

    储存液

    Azide free

    储存条件

    -20 °C,-80 °C

    储存方法

    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
  • 抗原

    TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7))

    别名

    TCF7

    背景

    Transcription Factor 7 (T-Cell Specific, HMG-Box), T-Cell-Specific Transcription Factor 1, T-Cell Factor 7

    adrenal gland or colon.|Human spleen|lung

    分子量

    41.6kDa

    基因ID

    6932, 573153

    UniProt

    P36402

    途径

    WNT signaling
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