Mannose Receptor 抗体 (AA 1-200)
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Quick Overview for Mannose Receptor 抗体 (AA 1-200) (ABIN7858610)
抗原
See all Mannose Receptor (MR) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-200
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原理
- Mannose Receptor / CD206 (Marker of M2 Macrophages) Antibody
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特异性
- CD206, also known as macrophage mannose receptor type C (MMR or MRC1), is a type I membrane receptor protein. It is an phagocytic and endocytic receptor that can recognize carbohydrate ligands in target molecules. The extracellular portion of the protein includes eight C-type carbohydrate recognition domains (CRD) which are clustered together to achieve higher affinity binding to saccharides. CD206 is found on macrophages and on endothelial cells of the liver and is the only known example of a C-type lectin that contains multiple C-type CRDs. CD206 mediates the endocytosis of glycoproteins by macrophages and binds high-mannose structures on the surface of potentially pathogenic viruses, fungi and bacteria enabling them to be neutralized by phagocytic engulfment. During inflammation, CD206 is crucial for rapid clearance of several mannose-bearing serum glycoproteins but does not regulate the initiation of inflammation. CD206 is primarily expressed in mature tissue macrophages and immature dendritic cells, as well as hepatic and lymphatic endothelial cells, retinal pigmental epithelium (RPE) and mesangial cells.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (around aa 1-200) of human MRC1 protein (exact sequence is proprietary)
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亚型
- IgG2b, kappa
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anti-Mannose Receptor (MR) antibody
KD Validated MR 适用: 人 FACS, WB, IF (p) 宿主: 兔 Monoclonal 25GB2060 unconjugated Recombinant Antibody
anti-Mannose Receptor (MR) antibodyMR 适用: 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Mannose Receptor (MR) (AA 22-131) antibodyMR 适用: 人 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 5C11 unconjugated
anti-Mannose Receptor (MR) (AA 359-388) antibodyMR 适用: 人, 小鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Mannose Receptor (MR) antibodyMR 适用: 人 IHC, IHC (fro) 宿主: 小鼠 Monoclonal 7-450 unconjugated
anti-Mannose Receptor (MR) antibodyMR 适用: 人 FACS, WB, IHC, IHC (fro) 宿主: 小鼠 Monoclonal 15-2 unconjugated
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- Mannose Receptor (MR)
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别名
- Mannose Receptor
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背景
- C-type lectin domain family 13 member D, human mannose receptor, macrophage mannose receptor 1-like protein 1, mannose receptor, C type 1-like 1
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分子量
- ~170kDa
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基因ID
- 4360, 75182
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UniProt
- P22897
抗原
-
