Kallikrein 4 抗体 (AA 1-200)
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Quick Overview for Kallikrein 4 抗体 (AA 1-200) (ABIN7858592)
抗原
See all Kallikrein 4 (KLK4) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-200
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原理
- KLK4 / Kallikrein related peptidase 4 Antibody
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特异性
- Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Human pancreatic/renal KLK encodes for the KLK1 enzyme, which is involved in post-translational processing of polypeptide precursors. The function of the other members of KLK gene family is still currently unknown, but evidence suggests that many KLKs are implicated in carcinogenesis. The human KLK gene family consists of 15 serine proteases. The human KLK genes are clustered on chromosome 19q13. Unlike other kalllikreins, the KLK4-15 encoded proteases are less related and do not contain a conventional KLK loop. Clusters of genes exhibit high prostatic (KLK2-4, KLK15) or pancreatic (KLK6-13) expression. KLK2 is also known as glandular kallikrein 2, tissue kallikrein, or HGK-1 and KLK3 is known as prostate-specific antigen (PSA). Both KLK2 and KLK3 have important applications in prostate cancer and breast cancer diagnostics. Many of the KLKs are regulated by steroid hormones and a few of them, specifically KLK3, KLK6 and KLK10, are known to be downregulated in breast and other cancers. KLK4 expression is abundant in skin, mammary gland and testis.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment of human KLK4 protein (around aa 1-200) (exact sequence is proprietary)
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亚型
- IgG2b, kappa
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anti-Kallikrein-Related Peptidase 4 (KLK4) (AA 32-256) antibody
KLK4 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Kallikrein-Related Peptidase 4 (KLK4) (AA 32-255) antibodyKLK4 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Kallikrein-Related Peptidase 4 (KLK4) (AA 159-254) antibodyKLK4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2A4 unconjugated
anti-Kallikrein-Related Peptidase 4 (KLK4) (AA 30-254) antibodyKLK4 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Kallikrein-Related Peptidase 4 (KLK4) (AA 31-254) antibodyKLK4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Kallikrein-Related Peptidase 4 (KLK4) (AA 27-254) antibodyKLK4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Kallikrein-Related Peptidase 4 (KLK4) (AA 85-115) antibodyKLK4 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB6105 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- Kallikrein 4 (KLK4) (Kallikrein-Related Peptidase 4 (KLK4))
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别名
- KLK4
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背景
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7S nerve growth factor alpha chain, AI2A1, Alpha-NGF, Androgen-regulated message 1, ARM1, EC 3.4.21.-, EMSP1, Enamel Matrix Serine Protease 1, HK4, Kallikrein 4, Kallikrein L1, Kallikrein like protein 1, Kallikrein related-peptidase 4 (prostase, enamel matrix, prostate), KLK-L1, KLK4, Protease Serine 17, PRSS17, PSTS, Serine protease 17
Human skin tissue (IHC).
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分子量
- 28-37kDa
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基因ID
- 9622, 218366
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UniProt
- Q9Y5K2
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途径
- Complement System
抗原
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