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Tyrosinase-Related Protein 1 抗体 (AA 200-400)

This 兔 单克隆 antibody specifically detects Tyrosinase-Related Protein 1 in IHC. It exhibits reactivity toward 人.
产品编号 ABIN7863788
发货至: 中国
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Quick Overview for Tyrosinase-Related Protein 1 抗体 (AA 200-400) (ABIN7863788)

抗原

See all Tyrosinase-Related Protein 1 (TYRP1) 抗体
Tyrosinase-Related Protein 1 (TYRP1)

适用

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宿主

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克隆类型

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单克隆

标记

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This Tyrosinase-Related Protein 1 antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC)

克隆位点

TYRP1-8313R
  • 抗原表位

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    AA 200-400

    原理

    Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) Antibody

    特异性

    It reacts with a 75 kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. 79oΩRecent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

    纯化方法

    200ug/ml of Ab purified by Protein A.

    免疫原

    Recombinant fragment (around aa200-400) of human TYRP1 protein (exact sequence is proprietary)

    亚型

    IgG, kappa
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 浓度

    200 μg/mL

    缓冲液

    Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
  • 抗原

    Tyrosinase-Related Protein 1 (TYRP1)

    别名

    Tyrosinase-Related Protein-1

    背景

    5, 6 dihydroxyindole 2 carboxylic acid oxidase, 6-dihydroxyindole-2-carboxylic acid oxidase, Associated with iris pigmentation, CAS2, Catalase B (CATB), DHICA oxidase, Glycoprotein75 (GP75), Melanoma antigen gp75, Tyrosinase-related protein 1 (TYRP1), TYRRP

    SK-MEL-19|SK-MEL-23|SK-MEL-30 or SK-MEL-37 cells. Human melanoma.

    分子量

    75kDa

    基因ID

    7306, 270279

    UniProt

    P17643
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