Recombinant TGFB1 抗体
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Quick Overview for Recombinant TGFB1 抗体 (ABIN7828634)
抗原
See all TGFB1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Recombinant TGF beta 1 Monoclonal Antibody
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纯化方法
- Protein A purified
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免疫原
- Recombinant human TGF beta 1 fragment
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亚型
- IgG, kappa
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应用备注
- WB 1:1000,IHC 1:500-1:1000
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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有效期
- 12 months
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- TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))
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别名
- TGF beta 1
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背景
- DPD,Transforming growth factor beta,TGF-B,TGFB1,CED,DPD1,LAP,TGFB,TGFbeta,TGF-β,Cartilage-inducing factor,Differentiation inhibiting factor,IBDIMDE,TGF-B1,TGF-beta 1,TGF-beta-1,TGF-β1,Transforming growth factor beta-1 proprotein,Latency-associated peptide,Transforming growth factor beta-1,beta 1,Prepro transforming growth factor beta 1,TGF beta,TGF beta 1,TGF beta 1 protein,Tgfb-1,TGF-beta 1 protein,TGFbeta1,TGF-beta1,TGF-beta-5,transforming growth factor,Transforming Growth Factor b1,Transforming Growth Factor beta 1,Transforming growth factor beta 1a,Transforming Growth Factor-1,Transforming growth factor-β (TGF-β) superfamily members are critical regulators of cell proliferation and differentiation, developmental patterning and morphogenesis, and disease pathogenesis. TGF-β elicits signaling through three cell surface receptors: type I (RI), type II (RII), and type III (RIII). Type I and type II receptors are serine/threonine kinases that form a heteromeric complex. In response to ligand binding, the type II receptors form a stable complex with the type I receptors allowing phosphorylation and activation of type I receptor kinases. The type III receptor, also known as betaglycan, is a transmembrane proteoglycan with a large extracellular domain that binds TGF-β with high affinity but lacks a cytoplasmic signaling domain. Expression of the type III receptor can regulate TGF-β signaling through presentation of the ligand to the signaling complex. The only known direct TGF-β signaling effectors are the Smad family proteins, which transduce signals from the cell surface directly to the nucleus to regulate target gene transcription. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [
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分子量
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Calculated MW: 44 kDa
Observed MW: 44, 10 kDa The actual band is not consistent with the expectation.
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UniProt
- P01137
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途径
- EGFR Signaling Pathway, Dopaminergic Neurogenesis, Cellular Response to Molecule of Bacterial Origin, Glycosaminoglycan Metabolic Process, Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy, Cancer Immune Checkpoints
抗原
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