Recombinant BTK 抗体 (pTyr551)
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Quick Overview for Recombinant BTK 抗体 (pTyr551) (ABIN7828051)
抗原
See all BTK 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pTyr551
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原理
- Recombinant Phospho-BTK (Tyr551) Monoclonal Antibody
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纯化方法
- Protein A purified
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亚型
- IgG, kappa
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anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) antibody
BTK 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (AA 27-55) antibodyBTK 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (AA 209-239) antibodyBTK 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (pSer180) antibodyBTK 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (AA 254-443) antibodyBTK 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (AA 91-387) antibodyBTK 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (C-Term) antibodyBTK 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) antibodyBTK 适用: 人, 猴 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 7F12H4 unconjugated
anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (pTyr223) antibodyBTK 适用: 人, 小鼠 ELISA, IF (cc), IF (p), FACS, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (pTyr551) antibodyBTK 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- FCM 1:100
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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有效期
- 12 months
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- BTK (Bruton Agammaglobulinemia tyrosine Kinase (BTK))
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别名
- BTK
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背景
- IMD,AGMX,PSCTK,AGMX1,AT,ATK,BPK,IMD1,PSCTK1,XLA,BTK,Bruton tyrosine kinase,AGMX1,ATK,BPK,Bruton tyrosine kinase,IMD1,PSCTK1,XLA,Bruton's tyrosine kinase (Btk) is a member of the Btk/Tec family of cytoplasmic tyrosine kinases. Like other Btk family members, it contains apleckstrin homology (PH) domain and Src homology SH3 and SH2 domains. Btk plays an important role in B cell development. Activation ofB cells by various ligands is accompanied by Btk membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane-localized Btk is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 andTyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinases, leading to autophosphorylation at Tyr223 withinthe SH3 domain, which is necessary for full activation. The activation of Btk is negatively regulated by PKCβ through phosphorylation of Btkat Ser180, which results in reduced membrane recruitment, transphosphorylation, and subsequent activation. The PKC inhibitory signal islikely to be a key determinant of the B cell receptor signaling threshold to maintain optimal Btk activity. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [
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UniProt
- Q06187
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途径
- Fc-epsilon Receptor Signaling Pathway, Hormone Transport, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, BCR Signaling
抗原
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