Recombinant ASCL1 抗体
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北京 101111
Quick Overview for Recombinant ASCL1 抗体 (ABIN7827989)
抗原
See all ASCL1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Recombinant MASH1 Monoclonal Antibody
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纯化方法
- Protein A purified
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亚型
- IgG, kappa
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anti-Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1) (AA 151-236) antibody
ASCL1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1) antibodyASCL1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1) (AA 137-236) antibodyASCL1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D3 unconjugated
anti-Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1) (N-Term) antibodyASCL1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 犬, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1) (AA 84-236) antibodyASCL1 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1) (AA 1-236) antibodyASCL1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1) (AA 137-236) antibodyASCL1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1) (C-Term) antibodyASCL1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1) (AA 137-236) antibodyASCL1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2D9 unconjugated
anti-Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1) (AA 48-97) antibodyASCL1 适用: 人, Cow, 豚鼠, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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有效期
- 12 months
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- ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))
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别名
- MASH1
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背景
- ASH,ASCL,HASH,MASH,bHLHa,ASCL1,ASH1,HASH1,MASH1,bHLHa46,Achaete scute complex homolog 1,Achaete scute complex homolog like 1,Achaete scute complex homologue 1,Achaete scute complex homologue like 1,Achaete scute complex like 1,Achaete scute family bHLH transcription factor 1,Achaete scute protein,Achaete-scute homolog 1,Ascl 1,Ash 1,ASH-1,Class A basic helix-loop-helix protein 46,Hash 1,Mammalian achaete scute homolog 1,Mammalian achaete scute homologue 1,Mash 1,MASH1, also known as achaete-scute homolog 1 (ASCL1), is a basic helix-loop-helix (BHLH) transcription factor which plays an essential role in the differentiation of neuroendocrine cells and neural tissues. MASH1 directly binds the E-box motif (5'-CANNTG-3') on promoters, with dimerization with other BHLH proteins required for efficient DNA binding. Acting as a pioneer transcription factor, MASH1 also accesses closed chromatin, allowing other factors to promote transcription of neuronal genes and activate neural pathways. Research studies have shown that knockdown of the MASH1 gene leads to inhibition of growth and induction of apoptosis in SCLC cells in vitro. Additionally, MASH1 is overexpressed in both classic SCLC as well as NSCLC with neuroendocrine features, suggesting its role in the pathogenesis of those malignancies. MASH1 plays a crucial role in promoting SCLC carcinogenesis by upregulating the expression of DLL3, a nonfunctioning Notch ligand, leading to inhibition of the Notch signaling pathway. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [
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分子量
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Calculated MW: 25 kDa
Observed MW: 30 kDa The actual band is not consistent with the expectation.
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UniProt
- P50553
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途径
- Dopaminergic Neurogenesis
抗原
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