我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

NRF2 抗体 (AA 430-480)

Name: NRF2 抗体 (AA 430-480)
SKU: ABIN737271
Availability: OutOfStock

Cited in 22+ publications. This anti-NRF2 antibody is a 兔多克隆 antibody detecting NRF2 in WB, ELISA, FACS, IHC (p), IF (cc), IF (p) 和 IHC (fro). Suitable for 人, 小鼠和大鼠.

Image submitted by One World Lab validation program. (NRF2 抗体 (AA 430-480))

Formalin-fixed and paraffin embedded human endometrial cancer labeled with Rabbit Anti-Nrf2 Polyclonal Antibody, Unconjugated (ABIN737271) 1:200 followed by conjugation to the secondary antibody and DAB staining (NRF2 抗体 (AA 430-480))

IHC

Formalin-fixed and paraffin embedded mouse myocardium labeled with (ABIN737271) Rabbit Anti-Nrf2 Polyclonal Antibody, Unconjugated 1:300 followed by conjugation to the secondary antibody and DAB staining (NRF2 抗体 (AA 430-480))

IHC

Rat brain lysates probed with Anti Nrf2 Polyclonal Antibody, Unconjugated (ABIN737271) at 1:200 overnight at 4 °C. (NRF2 抗体 (AA 430-480))

SDS

Rat brain lysates probed with Anti Nrf2 Polyclonal Antibody, Unconjugated at 1:200 overnight at 4˚C. (NRF2 抗体 (AA 430-480))

5 images

(22 references)

产品编号 ABIN737271

发货至: 中国

Contact our Customer Service for availability and price in your country. Contact Info

Our Local Distributor

中国
北京 101111

No. 88 KeChuang 6th Street

Beijing Economic Technological Development Area

Room 801-803

4A Biotech Co.,Ltd.

Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for NRF2 抗体 (AA 430-480) (ABIN737271)

抗原

See all NRF2 (NFE2L2) 抗体

NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This NRF2 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Discover our top product NFE2L2 Primary Antibody

抗原表位
37

14

11

8

8

5

5

4

3

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 430-480

交叉反应

小鸡, 人, 小鼠, Pig, 兔, 大鼠

预测反应

Dog,Cow,Horse

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human Nrf2

亚型

IgG
anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (pSer40) antibody
NFE2L2 适用: 人, 小鼠, 大鼠, Pig WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (AA 366-605) antibody
NFE2L2 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (Internal Region) antibody
NFE2L2 适用: 人, 大鼠 WB, IF, IP, ICC, IHC (p), ChIP 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (AA 382-604) antibody
NFE2L2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (acLys599) antibody
NFE2L2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (acLys599) antibody
NFE2L2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (N-Term) antibody
NFE2L2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (AA 356-589) antibody
NFE2L2 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 1A6G6 unconjugated

anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (pSer40) antibody
NFE2L2 适用: 人, 小鼠, 大鼠 WB, FACS, IHC (p), IF (cc) 宿主: 兔 Monoclonal 7G4 unconjugated

anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) (AA 445-458) antibody
Verified NFE2L2 适用: 人 WB, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated

应用备注

WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Xu, Zheng, Liu, Li, Yang, Shang: "Glaucocalyxin B Alleviates Lipopolysaccharide-Induced Parkinson's Disease by Inhibiting TLR/NF-κB and Activating Nrf2/HO-1 Pathway." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 44, Issue 6, pp. 2091-2104, (2018) (PubMed).

Zeng, Li, Zhang, Liu, Li, Xiong, He, Wang, Ye: "Tert-Butylhydroquinone Protects Liver Against Ischemia/Reperfusion Injury in Rats Through Nrf2-Activating Anti-Oxidative Activity." in: Transplantation proceedings, Vol. 49, Issue 2, pp. 366-372, (2017) (PubMed).

Zhang, Dong, Chen, Liu, Huang, Zhong, Cheng, Wang: "Nrf2 mediates the protective effects of homocysteine by increasing the levels of GSH content in HepG2 cells." in: Molecular medicine reports, Vol. 16, Issue 1, pp. 597-602, (2017) (PubMed).

Yu, Bei, Li, Han, Zhong, Liu, Zhao, Zhu, Zhao: "In vitro the differences of inflammatory and oxidative reactions due to sulfur mustard induced acute pulmonary injury underlying intraperitoneal injection and intratracheal instillation in rats." in: International immunopharmacology, Vol. 47, pp. 78-87, (2017) (PubMed).

Shen, Wu, Wang, Zhao, Zhang, Li, Zhao: "Chloroquine attenuates paraquat-induced lung injury in mice by altering inflammation, oxidative stress and fibrosis." in: International immunopharmacology, Vol. 46, pp. 16-22, (2017) (PubMed).

Zhang, Wang, Hao, Wang, Zhang, Muhammad, Qi, Li, Sun: "Nrf2 is crucial for the down-regulation of Cyp7a1 induced by arachidonic acid in Hepg2 cells." in: Environmental toxicology and pharmacology, Vol. 52, pp. 21-26, (2017) (PubMed).

Cao, Huang, Dou, Xiang, Dong: "Cyanidin suppresses autophagic activity regulating chondrocyte hypertrophic differentiation." in: Journal of cellular physiology, Vol. 233, Issue 3, pp. 2332-2342, (2017) (PubMed).

Kouam, Yuan, Njayou, He, Tsayem, Oladejo, Song, Moundipa, Gao: "Induction of Mkp-1 and Nuclear Translocation of Nrf2 by Limonoids from Khaya grandifoliola C.DC Protect L-02 Hepatocytes against Acetaminophen-Induced Hepatotoxicity." in: Frontiers in pharmacology, Vol. 8, pp. 653, (2017) (PubMed).

Jiang, Li, He, Yao, Bian, Wang, Zhu: "Protective Effects of Asiatic Acid Against Spinal Cord Injury-Induced Acute Lung Injury in Rats." in: Inflammation, Vol. 39, Issue 6, pp. 1853-1861, (2016) (PubMed).

Tang, Gao, Mao, He, Liu, Cai, Lin, Wu: "Salidroside protects against bleomycin-induced pulmonary fibrosis: activation of Nrf2-antioxidant signaling, and inhibition of NF-κB and TGF-β1/Smad-2/-3 pathways." in: Cell stress & chaperones, Vol. 21, Issue 2, pp. 239-49, (2016) (PubMed).

Wang, Peng, Wei, Wei, Wang, Ma, Yao, Fu, Zu: "Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathway." in: Biochimica et biophysica acta, Vol. 1850, Issue 9, pp. 1751-61, (2015) (PubMed).

Yu, Shi, Zhao, Sun, Gao, Sun, Qi: "Triptolide Attenuates Myocardial Ischemia/Reperfusion Injuries in Rats by Inducing the Activation of Nrf2/HO-1 Defense Pathway." in: Cardiovascular toxicology, (2015) (PubMed).

Lv, Mao, Wu, Lu, Ding, Gu, Wu, Shi: "Neuroprotective effect of allicin in a rat model of acute spinal cord injury." in: Life sciences, Vol. 143, pp. 114-23, (2015) (PubMed).

Lee, Lee, Wu: "Actinidia callosa peel (kiwi fruit) ethanol extracts protected neural cells apoptosis induced by methylglyoxal through Nrf2 activation." in: Pharmaceutical biology, Vol. 52, Issue 5, pp. 628-36, (2014) (PubMed).

Wang, Fang, Huang, Chen, Fan, Wang: "The chronic effects of low lead level on the expressions of Nrf2 and Mrp1 of the testes in the rats." in: Environmental toxicology and pharmacology, Vol. 35, Issue 1, pp. 109-16, (2013) (PubMed).

Lee, Hsu, Huang, Chang, Hsu, Pan: "Effects of monascin on anti-inflammation mediated by Nrf2 activation in advanced glycation end product-treated THP-1 monocytes and methylglyoxal-treated wistar rats." in: Journal of agricultural and food chemistry, Vol. 61, Issue 6, pp. 1288-98, (2013) (PubMed).

Hsu, Lee, Li, Hsu, Pan: "Monascin and AITC attenuate methylglyoxal-induced PPAR? phosphorylation and degradation through inhibition of the oxidative stress/PKC pathway depending on Nrf2 activation." in: Journal of agricultural and food chemistry, Vol. 61, Issue 25, pp. 5996-6006, (2013) (PubMed).

Lee, Hsu, Hsu, Pan: "Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid." in: Free radical biology & medicine, Vol. 60, pp. 7-16, (2013) (PubMed).

Lee, Lee, Cheng, Chang, Hsu, Wu: "Graptopetalum paraguayense and resveratrol ameliorates carboxymethyllysine (CML)-induced pancreas dysfunction and hyperglycemia." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 62, pp. 492-8, (2013) (PubMed).
抗原

NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))

别名

Nrf2

背景

Synonyms: NRF2, Nuclear factor erythroid 2-related factor 2, NF-E2-related factor 2, NFE2-related factor 2, HEBP1, Nuclear factor, erythroid derived 2, like 2, NFE2L2
Background: Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

基因ID

4780

UniProt

Q16236

途径

ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling