我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

Parkin 抗体 (AA 361-465)

Name: Parkin 抗体 (AA 361-465)
SKU: ABIN735578
Availability: OutOfStock

This anti-Parkin antibody is a 兔多克隆 antibody detecting Parkin in WB, ELISA, IF (cc), IF (p), FACS, IHC (p) 和 IHC (fro). Suitable for 大鼠. This Primary Antibody has been cited in 1 publication.

Formalin-fixed and paraffin embedded rat brain labeled with Anti-Parkin protein/PARK2 Polyclonal Antibody, Unconjugated (ABIN735578) at 1:200 followed by conjugation to the secondary antibody and DAB staining. (Parkin 抗体 (AA 361-465))

IHC

Formalin-fixed and paraffin embedded rat testis labeled with Anti-Parkin protein/PARK2 Polyclonal Antibody, Unconjugated (ABIN735578) at 1:200 followed by conjugation to the secondary antibody and DAB staining (Parkin 抗体 (AA 361-465))

IHC

RSC96 cells probed with Rabbit Anti-Parkin/PARK2 Polyclonal Antibody. (Parkin 抗体 (AA 361-465))

FACS

3 images

(1 reference)

产品编号 ABIN735578

发货至: 中国

Quick Overview for Parkin 抗体 (AA 361-465) (ABIN735578)

抗原

See all Parkin (PARK2) 抗体

Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))

适用

大鼠

宿主

兔

克隆类型

多克隆

标记

This Parkin antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Discover our top product PARK2 Primary Antibody

抗原表位
18

17

15

9

9

6

6

4

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 361-465

交叉反应

大鼠

预测反应

Human,Mouse,Pig

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human E3 ubiquitin-protein ligase parkin

亚型

IgG
anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 288-387) antibody
PARK2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1H4 unconjugated

anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 1-300) antibody
PARK2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 387-417), (C-Term) antibody
PARK2 适用: 人, 小鼠 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB07373 unconjugated

anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 387-417) antibody
PARK2 适用: 人, 小鼠 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 111-140) antibody
PARK2 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 1-465) antibody
PARK2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 1-144) antibody
PARK2 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 6F5D2 unconjugated

anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 23-416) antibody
PARK2 适用: 人, 小鼠, 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated

anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (pSer378) antibody
PARK2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 311-360) antibody
PARK2 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Li, Zhang, Wang, Liu, Yang, Liu, Lu: "Neuroprotective effects of extract of Acanthopanax senticosus harms on SH-SY5Y cells overexpressing wild-type or A53T mutant ?-synuclein." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 21, Issue 5, pp. 704-11, (2014) (PubMed).
抗原

Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))

别名

PARK2

背景

Synonyms: PDJ, PRKN, AR-JP, LPRS2, E3 ubiquitin-protein ligase parkin, Parkinson juvenile disease protein 2, Parkinson disease protein 2, PARK2
Background: Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5, TOMM2, USP3, ZNF746 and AIMP2. Mediates monoubiquitination as well as 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation. Mediates 'Lys-63'-linked polyubiquitination of SNCAIP, possibly playing a role in Lewy-body formation. Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy. Promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by the ubiquitination of mitochondrial proteins such as TOMM2, RHOT1/MIRO1 and USP3 (PubMed:24896179). Mediates 'Lys-48'-linked polyubiquitination of ZNF746, followed by degradation of ZNF746 by the proteasome, possibly playing a role in the regulation of neuron death. Limits the production of reactive oxygen species (ROS). Regulates cyclin-E during neuronal apoptosis. In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress. Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene.

基因ID

5071

UniProt

O60260

途径

Autophagy, Ubiquitin Proteasome Pathway