VEGFR2/CD309 抗体 (pTyr1175)
Quick Overview for VEGFR2/CD309 抗体 (pTyr1175) (ABIN7674409)
抗原
See all VEGFR2/CD309 (VEGFR2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pTyr1175
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原理
- Phospho-VEGF Receptor 2 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- A phospho specific peptide corresponding to residues surrounding Y1175 of human VEGF Receptor 2
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亚型
- IgG
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应用备注
- WB: 1:500 - 1:1000, IHC: 1:50 - 1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
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有效期
- 12 months
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- VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))
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别名
- VEGF Receptor 2
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背景
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Synonyms: Vascular endothelial growth factor receptor 2 (VEGFR-2)|Fetal liver kinase 1 (FLK-1)|Kinase insert domain receptor (KDR)|Protein-tyrosine kinase receptor flk-1|KDR|FLK1|VEGFR2
Background: KDR, also named as VEGFR-2, FLK1 and CD309, is a receptor for VEGF or VEGFC. KDR which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. KDR functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas.
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分子量
- 250 kDa
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基因ID
- 3791
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UniProt
- P35968
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途径
- RTK signaling, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling
抗原
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