PAI1 抗体
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北京 101111
Quick Overview for PAI1 抗体 (ABIN7670718)
抗原
See all PAI1 (SERPINE1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Serpin E1/PAI-1 Monoclonal Antibody(Capture)
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纯化方法
- Protein A/G Purification
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免疫原
- Recombinant Human Serpin E1/PAI-1 Protein expressed by Mammalian
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亚型
- IgG2a
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anti-Plasminogen Activator Inhibitor 1 (SERPINE1) antibody
SERPINE1 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 1D5 unconjugated
anti-Plasminogen Activator Inhibitor 1 (SERPINE1) antibodySERPINE1 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C6 unconjugated
anti-Plasminogen Activator Inhibitor 1 (SERPINE1) (AA 24-402) antibodySERPINE1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Plasminogen Activator Inhibitor 1 (SERPINE1) (Internal Region) antibodyVerified SERPINE1 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Plasminogen Activator Inhibitor 1 (SERPINE1) (AA 86-185) antibodySERPINE1 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 3F2 unconjugated
anti-Plasminogen Activator Inhibitor 1 (SERPINE1) antibodySERPINE1 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C4 unconjugated
anti-Plasminogen Activator Inhibitor 1 (SERPINE1) (AA 24-402) antibodySERPINE1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Plasminogen Activator Inhibitor 1 (SERPINE1) antibodySERPINE1 适用: 人, 猴 WB, IHC, FACS, IHC (p) 宿主: 小鼠 Monoclonal 6F3 unconjugated
anti-Plasminogen Activator Inhibitor 1 (SERPINE1) (AA 141-389) antibodySERPINE1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Plasminogen Activator Inhibitor 1 (SERPINE1) (AA 24-398) antibodySERPINE1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- ELISA Capture 2-8 μg/mL
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Sterile PBS , pH 7.4
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储存液
- Without preservative
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注意事项
- Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C Valid for 1 month or -20°C Valid for 12 months
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有效期
- 12 months
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- PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))
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别名
- Serpin E1/PAI-1
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背景
- PLasminogen activator inhibitor 1,PAI-1,EndotheLiaL pLasminogen activator inhibitor,Serpin E1,SERPINE1,PLANH1,Plasminogen activator inhibitor 1,also known as PAI-1,Endothelial plasminogen activator inhibitor,SerpinE1 and PlANH1,is a secreted glycoprotein that belongs to the serpin family. SerpinE1 is the primary physiological inhibitor of the two plasminogen activators urokinase (uPA) and tissue plasminogen activator (tPA). Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Defects in SerpinE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency) which is characterized by abnormal bleeding due to SerpinE1 defect in the plasma. High concentrations of SerpinE1 have been associated with thrombophilia which is an autosomal dominant disorder in which affected individuals are prone to develop serious spontaneous thrombosis. Studies of PAI-1 have contributed significantly to the elucidation of the protease inhibitory mechanism of serpins,which is based on a metastable native state becoming stabilised by insertion of the RCl into the central beta-sheet A and formation of covalent complexes with target proteases. Greater expression of PAI-1 has been associated with increased survival of cells and resistance to apoptosis. PAI-1 appears to influence apoptosis by decreasing cell adhesion (anoikis) as well as its effect on intracellular signaling. PAI-1,in its active state,also binds to the extracellular protein vitronectin. When in complex with its target proteases,it binds with high affinity to endocytosis receptors of the low density receptor family. The mechanisms of PAI-1 overexpression during obesity are complex,and it is conceivable that several inducers are involved at the same time at several sites of synthesis. PAI-1 is also implicated in adipose tissue development. It suggests that PAI-1 inhibitors serve in the control of atherothrombosis.
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UniProt
- P05121
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途径
- p53 Pathway, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration
抗原
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