Caspase 4 抗体
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北京 101111
Quick Overview for Caspase 4 抗体 (ABIN7670548)
抗原
See all Caspase 4 (CASP4) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Caspase-4 Monoclonal Antibody(Capture)
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纯化方法
- Protein A/G Purification
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免疫原
- Recombinant Human Caspase-4 protein expressed by E.coli
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亚型
- IgG1
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anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (AA 1-377) antibody
CASP4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 7G7 unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (AA 290-377) antibodyCASP4 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (AA 82-226) antibodyCASP4 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) antibodyCASP4 适用: 小鼠, 大鼠 WB, ELISA, IP, FACS 宿主: 大鼠 Monoclonal 8A5 unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (cleaved), (Internal Region) antibodyCASP4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (AA 78-265) antibodyCASP4 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (AA 81-270) antibodyCASP4 适用: Cow WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (Internal Region) antibodyVerified CASP4 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (AA 111-194) antibodyCASP4 适用: 人 WB, IHC, ELISA, ICC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (AA 104-124) antibodyCASP4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- ELISA Capture 2-8 μg/mL
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Sterile PBS , pH 7.4
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储存液
- Without preservative
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注意事项
- Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C Valid for 1 month or -20°C Valid for 12 months
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有效期
- 12 months
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- Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))
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别名
- Caspase-4
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背景
- Caspase-4,CASP-4,ICE and Ced-3 homoLog 2,ICE(reL)-II,Mih1,Protease TX,CASP4,ICH2,Inflammatory caspase that acts as the effector of the non-canonical inflammasome by mediating lipopolysaccharide (lPS)-induced pyroptosis .Also indirectly activates the NlRP3 and NlRP6 inflammasomes. Acts as a thiol protease that cleaves a tetrapeptide after an Asp residue at position P1: catalyzes cleavage of CGAS,GSDMD and Il18 . Effector of the non-canonical inflammasome independently of NlRP3 inflammasome and CASP1: the non-canonical inflammasome promotes pyroptosis through GSDMD cleavage without involving secretion of cytokine Il1B and Il18 . In the non-canonical inflammasome,CASP4 is activated by direct binding to lPS without the need of an upstream sensor . lPS-binding promotes CASP4 activation and CASP4-mediated cleavage of GSDMD,followed by pyroptosis of infected cells and their extrusion into the gut lumen . Also indirectly promotes secretion of mature cytokines (Il1A,Il18 and HMGB1) downstream of GSDMD-mediated pyroptosis via activation of the NlRP3 and NlRP6 inflammasomes . Involved in NlRP3-dependent CASP1 activation and Il1B and Il18 secretion in response to non-canonical activators,such as UVB radiation or cholera enterotoxin . Involved in NlRP6 inflammasome-dependent activation in response to lipoteichoic acid (lTA),a cell-wall component of Gram-positive bacteria,which leads to CASP1 activation and Il1B and Il18 secretion . Involved in lPS-induced Il6 secretion,this activity may not require caspase enzymatic activity. The non-canonical inflammasome is required for innate immunity to cytosolic,but not vacuolar,bacteria. Plays a crucial role in the restriction of S.typhimurium replication in colonic epithelial cells during infection.
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UniProt
- P49662
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途径
- Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
抗原
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