CCR5 抗体
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北京 101111
Quick Overview for CCR5 抗体 (ABIN7670043)
抗原
See all CCR5 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Purified Anti-Human CD195 Antibody[RoAb13]
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亚型
- IgG2a, kappa
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- ≥ 1 mg/mL
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缓冲液
- Phosphate buffered solution, pH 7.2, containing 0.05 % proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- avoid freeze / thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
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有效期
- 12 months
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- CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))
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别名
- CD195
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背景
- IDDM,CCCKR,CMKBR,CC-CKR,CKR,CCR,CKR5,CCR-5,CD195,CKR-5,CCCKR5,CMKBR5,IDDM22,CC-CKR-5,CCR5,CCCKR5,CC-CKR-5,CCR-5,CD195,CKR-5,CMKBR5,IDDM22,This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles, the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene.
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UniProt
- P51681
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途径
- Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size
抗原
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