ADAM10 抗体
Quick Overview for ADAM10 抗体 (ABIN7669976)
抗原
See all ADAM10 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Purified Anti-Human ADAM10 Antibody[11G2]
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亚型
- IgG1, kappa
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anti-ADAM Metallopeptidase Domain 10 (ADAM10) (AA 420-641) antibody
ADAM10 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 10 (ADAM10) antibodyADAM10 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 6C3C7 unconjugated
anti-ADAM Metallopeptidase Domain 10 (ADAM10) (AA 400-414), (Extracellular) antibodyADAM10 适用: 小鼠 WB, IHC, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 10 (ADAM10) (AA 501-600) antibodyADAM10 适用: 人, 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 10 (ADAM10) antibodyADAM10 适用: 人 WB, FACS, IP, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal 11G2 unconjugated
anti-ADAM Metallopeptidase Domain 10 (ADAM10) (AA 732-748) antibodyADAM10 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 10 (ADAM10) antibody (PE)ADAM10 适用: 人 FACS 宿主: 小鼠 Monoclonal 11G2 PE
anti-ADAM Metallopeptidase Domain 10 (ADAM10) (AA 214-500) antibodyADAM10 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 10 (ADAM10) antibodyADAM10 适用: 人 WB, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-ADAM Metallopeptidase Domain 10 (ADAM10) (AA 218-445) antibodyADAM10 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- ≥ 1 mg/mL
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缓冲液
- Phosphate buffered solution, pH 7.2, containing 0.05 % proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- avoid freeze / thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
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有效期
- 12 months
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- ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))
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别名
- ADAM10
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背景
- CDw,ADAM,ADAM metallopeptidase domain,a disintegrin and metalloprotease domain,a disintegrin and metalloproteinase domain,disintegrin and metalloproteinase domain-containing protein,ADAM10,AD10,AD18,CD156c,CDw156,HsT18717,MADM,RAK,kuz,Kuzbanian,a disintegrin and metalloprotease domain 10,a disintegrin and metalloproteinase domain 10,ADAM metallopeptidase domain 10,CD156c antigen,disintegrin and metalloproteinase domain-containing protein 10,Kuzbanian protein homolog,Mammalian disintegrin-metalloprotease,ADAM metallopeptidase domain 10,CD156c,CDw156,HsT18717,kuz,MADM,AD 10,ADA10,ADAM 10,CD 156c,disintegrin and metalloproteinase domain containing protein 10,Drosophila,homolog of,HsT 18717,Mammalian disintegrin metalloprotease,ADAM10 (also known as Kuzbanian, mammalian disintegrin metalloprotease, myelin-associated metalloproteinase) is a member of the ADAM family that contains a disintegrin and metalloprotease-like domain . Like other membrane-anchored ADAMs, ADAM10 consists of the following domains, pro with a cysteine switch and furin cleavage sequence, catalytic with the zinc-binding site and Met-turn expected for reprolysins, disintegrin-like, cysteine-rich, EGF-like, transmembrane, and cytoplasmic. ADAM10 is highly conserved, with 97 % amino acid identity between mouse, rat, bovine and human and 45 % identity between mouse and Drosophila. The active enzyme processes notch, notch ligand delta, and amyloid protein precursor at the alpha site, playing an important role in neurogenesis . It also processes the 26 kDa membrane-anchored pro-tumor necrosis factor-alpha (TNF-alpha ) to the 17 kDa mature TNF-alpha. It cleaves myelin basic protein and type IV collagen. ADAM10 is widely expressed in tissues and resides both on the cell surface and in the cell.
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UniProt
- O14672
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途径
- Notch Signaling, EGFR Signaling Pathway
抗原
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