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Ret Proto-Oncogene 抗体 (AA 702-848) (CF®740)

This anti-Ret Proto-Oncogene antibody is a 小鼠 单克隆 antibody detecting Ret Proto-Oncogene in . Suitable for 人.
产品编号 ABIN7659588
发货至: 中国

Quick Overview for Ret Proto-Oncogene 抗体 (AA 702-848) (CF®740) (ABIN7659588)

抗原

See all Ret Proto-Oncogene (RET) 抗体
Ret Proto-Oncogene (RET)

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This Ret Proto-Oncogene antibody is conjugated to CF®740

应用范围

请咨询

克隆位点

RET-2662
  • 抗原表位

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    AA 702-848

    原理

    RET Proto-oncogene(RET/2662), CF740 conjugate

    产品特性

    The Ret proto-oncogene is structurally related to the growing family of tyrosine kinase transmembrane receptors and is involved in GDNF signaling. RET expression is reported in several regions of the central nervous system, in the developing cranial nerve ganglia and a subset of cells within dorsal root ganglia, in motor neurons in the spinal cord and hindbrain, in neuro-retina and the growing tips of the renal collecting ducts in developing kidney. Alterations in RETgene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma, and a congenital developmental disorder known as Hirschsprung's disease. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

    免疫原

    Recombinant fragment (around aa 702-848) of human RET protein

    亚型

    IgG2b, kappa
  • 应用备注

    For coating for ELISA, order Ab without BSA. Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Optimal dilution and staining procedure for a specific application should be determined by user. Recommended starting concentrations for titration are 1-2 μg/mL for most applications, or 1 μg/million cells/100 μLfor flow cytometry

    说明

    Positive Control: Breast, Prostate or Colon Carcinoma.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.1 mg/mL

    缓冲液

    PBS, 0.1 % rBSA, 0.05 % azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Protect from light

    储存条件

    4 °C

    储存方法

    Stable at room temperature or 37°C for 7 days.

    Protect from light

    Store at 2 to 8°C. Protect fluorescent conjugates from light

    有效期

    24 months
  • 抗原

    Ret Proto-Oncogene (RET)

    别名

    RET Proto-oncogene

    背景

    Synonyms: Cadherin family member 12 (CDHF12), Cadherin related family member 16 (CDHR16), ELKS, HSCR1, Hydroxyaryl protein kinase, MEN2A, MEN2B, MTC1, Multiple endocrine neoplasia and medullary thyroid carcinoma 1, Oncogene RET, Proto-oncogene c-Ret, Proto-oncogene tyrosine-protein kinase receptor ret, PTC, RET, RET ELE1, RET51, RET9

    Gene Symbol: RET

    分子量

    150 kDa (precursor), 170 kDa (Mature)

    基因ID

    5979

    UniProt

    P07949

    途径

    RTK signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation
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