Ret Proto-Oncogene 抗体 (Extracellular, N-Term)
Our Local Distributor
北京 101111
Quick Overview for Ret Proto-Oncogene 抗体 (Extracellular, N-Term) (ABIN7043600)
抗原
See all Ret Proto-Oncogene (RET) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 541-553, Extracellular, N-Term
-
原理
- A Rabbit Polyclonal Antibody to Ret Receptor
-
交叉反应
- 人, 小鼠, 大鼠
-
交叉反应 （详细）
- This antibody will recognize the intact Ret receptor and the cleaved Ret extracellular cell-membrane anchored fragment. It won't recognize the cleaved Ret kinase fragment.
-
预测反应
- Mouse - identical, rat - 12,13 amino acid residues identical
-
产品特性
- Anti-Ret (extracellular) Antibody is directed against an extracellular epitope of human Ret. Anti-Ret (extracellular) Antibody ( (ABIN7043600, ABIN7044783 and ABIN7044784) can be used in western blot, indirect flow cytometry, immunohistochemistry and immunocytochemistry applications and has been designed to recognize Ret from rat, mouse and human samples.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
- CEWRQGDGKGITR, corresponding to amino acid residues 541-553 of human Ret
-
亚型
- IgG
-
-
anti-Ret Proto-Oncogene (RET) (AA 702-848) antibody
RET 适用: 人 IHC 宿主: 小鼠 Monoclonal RET-2795 unconjugated
anti-Ret Proto-Oncogene (RET) (AA 1-1072) antibodyRET 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Ret Proto-Oncogene (RET) (AA 702-848) antibodyRET 适用: 人 ELISA 宿主: 小鼠 Monoclonal RET-2663 unconjugated
anti-Ret Proto-Oncogene (RET) (AA 361-458) antibodyRET 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 1A5 unconjugated
anti-Ret Proto-Oncogene (RET) (pTyr1062) antibodyRET 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ret Proto-Oncogene (RET) (C-Term) antibodyRET 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ret Proto-Oncogene (RET) (AA 152-182), (N-Term) antibodyRET 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB00705 unconjugated
anti-Ret Proto-Oncogene (RET) (AA 1012-1042), (C-Term) antibodyRET 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB01561 unconjugated
anti-Ret Proto-Oncogene (RET) (pTyr905) antibodyRET 适用: 人, 小鼠 WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ret Proto-Oncogene (RET) (AA 1001-1114) antibodyRET 适用: 小鼠, 大鼠 WB, ELISA, IF (p), IF (cc), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
WB: 1:200
FC: 5 μg per reaction
ICC: 1:25
IHC: 1:50
IP: The optimal concentration should be determined by the user
-
说明
-
Cited Application: ICC
Negative Control: (ABIN7236725)
Blocking Peptide: (ABIN7236725)
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
-
浓度
- 0.8 mg/mL
-
缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
-
-
- Ret Proto-Oncogene (RET)
-
别名
- RET
-
背景
-
Synonyms: Proto-oncogene tyrosine-protein kinase receptor Ret, Proto-oncogene c-Ret, Cadherin family member 12, CDHF12
Description: The RET proto-oncogene on human chromosome 10q11.2, encodes a receptor tyrosine kinase (RTK) activated by members of the glial cell line-derived neurotrophic factor (GDNF) ligand family (GDNF, neurturin, artemin, and persephin) in conjunction with a ligand-specific coreceptor (GFRα1-4)1. RET belongs to the cadherin superfamily, and it has been suggested that the ret gene is the result of a recombination between a gene encoding a tyrosine kinase receptor and a gene encoding an ancestral cadherin at an early stage of evolution2. The extracellular domain of RET comprises, as observed for other tyrosine kinase receptors, a cysteine-rich domain, but also four cadherin-like domains3.RET signaling is crucial for the development of the enteric nervous system. RET also regulates the development of sympathetic, parasympathetic, motor, and sensory neurons, and is necessary for the postnatal maintenance of dopaminergic neurons. Outside the nervous system, RET is crucial for development of the kidney and plays a key role in spermatogenesis3.RET has attracted considerable clinical interest because of the range of mutations found in diverse conditions that include Hirschsprung disease and a variety of cancers involving the thyroid gland. RET-related cancers with thyroid involvement include sporadic and familial medullary thyroid carcinoma (MTC), multiple endocrine neoplasia 2 (MEN2) syndromes MEN2A and MEN2B, and papillary thyroid carcinoma (PTC)4.
-
基因ID
- 5979
-
NCBI登录号
- NM_020975
-
UniProt
- P07949
-
途径
- RTK signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation
抗原
-
