Ret Proto-Oncogene 抗体 (AA 702-848) (CF®405S)
Quick Overview for Ret Proto-Oncogene 抗体 (AA 702-848) (CF®405S) (ABIN7659569)
抗原
See all Ret Proto-Oncogene (RET) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 702-848
-
原理
- RET Proto-oncogene(RET/2663), CF405S conjugate
-
产品特性
- The Ret proto-oncogene is structurally related to the growing family of tyrosine kinase transmembrane receptors and is involved in GDNF signaling. RET expression is reported in several regions of the central nervous system, in the developing cranial nerve ganglia and a subset of cells within dorsal root ganglia, in motor neurons in the spinal cord and hindbrain, in neuro-retina and the growing tips of the renal collecting ducts in developing kidney. Alterations in RETgene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma, and a congenital developmental disorder known as Hirschsprung's disease. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
-
免疫原
- Recombinant fragment (around aa 702-848) of human RET protein
-
亚型
- IgG2b, kappa
-
-
-
-
应用备注
- For coating for ELISA, order Ab without BSA. Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Optimal dilution and staining procedure for a specific application should be determined by user. Recommended starting concentrations for titration are 1-2 μg/mL for most applications, or 1 μg/million cells/100 μLfor flow cytometry
-
说明
-
Positive Control: Breast, Prostate or Colon Carcinoma.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 0.1 mg/mL
-
缓冲液
- PBS, 0.1 % BSA, 0.05 % azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Protect from light
-
储存条件
- 4 °C
-
储存方法
-
Stable at room temperature or 37°C for 7 days.
Protect from light
Store at 2 to 8°C. Protect fluorescent conjugates from light
-
有效期
- 24 months
-
-
- Ret Proto-Oncogene (RET)
-
别名
- RET Proto-oncogene
-
背景
-
Synonyms: Cadherin family member 12 (CDHF12), Cadherin related family member 16 (CDHR16), ELKS, HSCR1, Hydroxyaryl protein kinase, MEN2A, MEN2B, MTC1, Multiple endocrine neoplasia and medullary thyroid carcinoma 1, Oncogene RET, Proto-oncogene c-Ret, Proto-oncogene tyrosine-protein kinase receptor ret, PTC, RET, RET ELE1, RET51, RET9
Gene Symbol: RET
-
分子量
- 150 kDa (precursor), 170 kDa (Mature)
-
基因ID
- 5979
-
UniProt
- P07949
-
途径
- RTK signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation
抗原
-