SHP1 抗体 (CF®405S)
Quick Overview for SHP1 抗体 (CF®405S) (ABIN7659399)
抗原
See all SHP1 (PTPN6) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Protein Tyrosine Phosphatase, non-receptor type 6(CPTC-PTPN6-2), CF405S conjugate
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产品特性
- PTPN6, which is also designated as SHP-1, is expressed primarily in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. It maps to 12p13, a region commonly involved in leukemia-associated chromosomal abnormalities. SHP-1 plays a role in modulating intracellular signaling for various molecules. In T-cell lymphomas and other malignancies, SHP-1 phosphatase expression is lost, by a thus far undetermined mechanism. Preliminary studies suggest that it may be helpful in differentiating mantle/marginal zone lymphomas (SHP-1 ) from follicular lymphomas (SHP-1 negative). Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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免疫原
- Recombinant human full-length PTPN6 protein
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亚型
- IgG2a, kappa
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anti-Protein-tyrosine Phosphatase 1C (PTPN6) antibody
PTPN6 适用: 人 WB, IHC, IF, FACS, StM 宿主: 小鼠 Monoclonal CPTC-APEX1-2 unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) antibodyPTPN6 适用: 人 WB, IHC (p), IP, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 1-595) antibodyPTPN6 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 243-541) antibodyPTPN6 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 2E9E4 unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 1-597), (Isoform 2) antibodyPTPN6 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) (C-Term) antibodyPTPN6 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) (pTyr536) antibodyPTPN6 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 100-400) antibodyPTPN6 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 247-277) antibodyPTPN6 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB17225 unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) antibodyPTPN6 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- For coating for ELISA, order Ab without BSA. Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Optimal dilution and staining procedure for a specific application should be determined by user. Recommended starting concentrations for titration are 1-2 μg/mL for most applications, or 1 μg/million cells/100 μLfor flow cytometry
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说明
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Positive Control: A431, Jurkat or K562 cell lysates, Lymph node or spleen.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % BSA, 0.05 % azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Protect from light
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储存条件
- 4 °C
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储存方法
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Stable at room temperature or 37°C for 7 days.
Protect from light
Store at 2 to 8°C. Protect fluorescent conjugates from light
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有效期
- 24 months
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- SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))
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别名
- Protein Tyrosine Phosphatase, non-receptor type 6
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背景
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Synonyms: PTPN6, SHP1, protein tyrosine phosphatase, non-receptor type 6, HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, 70 kda SHP-1L protein, hematopoietic cell phosphatase, hematopoietic cell protein-tyrosine phosphatase, protein-tyrosine phosphatase 1C, PTPN6 / SHP
Gene Symbol: PTPN6
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分子量
- 65 kDa
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基因ID
- 5777
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UniProt
- P29350
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途径
- JAK/STAT Signaling, TCR Signaling, TLR signaling, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, BCR Signaling
抗原
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