PAK1/2/3 抗体 (pThr423)
Quick Overview for PAK1/2/3 抗体 (pThr423) (ABIN732548)
抗原
See all PAK1/2/3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pThr423
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交叉反应
- 人
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预测反应
- Mouse,Rat,Dog,Cow,Pig,Chicken,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic phosphopeptide derived from human PAK1 around the phosphorylation site of (Thr423)
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亚型
- IgG
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anti-P21-Activated Kinases 1/2/3 (PAK1/2/3) (Thr402), (Thr421), (Thr423) antibody
PAK1/2/3 适用: 人 IHC, ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinases 1/2/3 (PAK1/2/3) (Thr402), (Thr421), (Thr423) antibodyPAK1/2/3 适用: 人, 大鼠, 小鼠 IHC, ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinases 1/2/3 (PAK1/2/3) (pThr423) antibodyPAK1/2/3 适用: 人, 大鼠, 小鼠, Cow, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinases 1/2/3 (PAK1/2/3) (AA 391-440) antibodyPAK1/2/3 适用: 人, 大鼠, 小鼠 IHC, ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinases 1/2/3 (PAK1/2/3) (AA 111-160), (pSer144) antibodyPAK1/2/3 适用: 人, 大鼠, 小鼠 IHC, ELISA, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- PAK1/2/3 (P21-Activated Kinases 1/2/3 (PAK1/2/3))
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别名
- PAK1/2/3
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背景
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Synonyms: PAK1 + PAK2 + PAK3 phospho T423, Alpha PAK, Beta PAK, Gamma PAK, Oligophrenin 3, OPHN3, p21 activated kinase 1, p21 Activated Kinase 1 + 2 + 3, p21 activated kinase 2 , p21 activated kinase 3, P65 PAK, PAK1, PAK2, PAK3, PAK3beta, PAK65, PAKalpha, PAKgamma, S6/H4 kinase, Serine/threonine protein kinase PAK 1, Serine/threonine protein kinase PAK 2, Serine/threonine protein kinase PAK 3, Serine/threonine protein kinase PAK1, Serine/threonine protein kinase PAK2, Serine/threonine protein kinase PAK3, PAK1_HUMAN, PAK2_HUMAN, PAK3_HUMAN.
Background: The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.P21-activated kinase (PAK) is actually a family of serine/threonine protein kinases, members of which are activated by small molecular weight GTPases. The three most common isoforms are PAK 1, PAK 2, and PAK 3 (also known as alpha PAK, gamma PAK, and beta PAK, respectively). These kinases contain numerous regulatory elements that trigger diverse signaling processes such as those initiated by activated GTPases, interaction with Src homology 3 (SH3) domains, and caspase mediated proteolytic cleavage. Autophosphorylation of serine 141 (serine 144 for PAK 1 and serine 139 PAK 3), catalyzed by Cdc42, is required for activation of PAK.
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基因ID
- 5058
抗原
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