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Recombinant Nkx2-2 抗体 (AA 1-119) (CF®640R)

This anti-Nkx2-2 antibody is a 小鼠 单克隆 antibody detecting Nkx2-2 in IHC 和 IHC (fp). Suitable for 人.
产品编号 ABIN7657938
发货至: 中国

Quick Overview for Recombinant Nkx2-2 抗体 (AA 1-119) (CF®640R) (ABIN7657938)

抗原

See all Nkx2-2 抗体
Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))

抗体类型

Recombinant Antibody

适用

  • 130
  • 43
  • 40
  • 24
  • 6
  • 6
  • 6
  • 5
  • 5
  • 4
  • 2
  • 2
  • 2
  • 2

宿主

  • 76
  • 60
小鼠

克隆类型

  • 87
  • 49
单克隆

标记

  • 60
  • 12
  • 8
  • 7
  • 7
  • 7
  • 7
  • 7
  • 6
  • 5
  • 2
  • 1
  • 1
  • 1
  • 1
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  • 1
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  • 1
This Nkx2-2 antibody is conjugated to CF®640R

应用范围

  • 75
  • 50
  • 47
  • 34
  • 31
  • 23
  • 13
  • 12
  • 8
  • 7
  • 3
  • 2
Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

克隆位点

RNX2-1523
  • 抗原表位

    • 38
    • 7
    • 7
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-119

    原理

    NKX2.2 (Neuroendocrine & Ewing s Sarcoma Marker) (rNX2/1523), CF640R conjugate

    产品特性

    Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93 % and a specificity of 89 %, and aids in the differential diagnosis of small round cell tumors.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

    免疫原

    Human recombinant NKX2.2 protein fragment (around aa1-119)

    亚型

    IgG1
  • 应用备注

    Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Immunohistology (formalin): 0.5-1 μg/mL for 30 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at RT for 20 minutes. Optimal dilution for a specific application should be determined by user

    说明

    Positive Control: Pancreas or Ewing sarcoma

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.1 mg/mL

    缓冲液

    PBS, 0.1 % BSA, 0.05 % azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Protect from light

    储存条件

    4 °C

    储存方法

    Stable at room temperature or 37°C for 7 days.

    Protect from light

    Store at 2 to 8°C. Protect fluorescent conjugates from light

    有效期

    24 months
  • 抗原

    Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))

    别名

    NKX2.2

    背景

    Synonyms: Homeobox protein NK-2 homolog B, NK2 transcription factor like protein B, NK2 transcription factor related locus 2, NKX22, Nkx2b, tinman

    Gene Symbol: NKX2-2

    分子量

    40-50 kDa

    基因ID

    4821

    UniProt

    O95096

    途径

    Dopaminergic Neurogenesis
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