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LSP1 抗体 (AA 174-278) (CF®405S)

This anti-LSP1 antibody is a 小鼠 单克隆 antibody detecting LSP1 in IHC 和 IHC (fp). Suitable for 人.
产品编号 ABIN7656426
发货至: 中国

Quick Overview for LSP1 抗体 (AA 174-278) (CF®405S) (ABIN7656426)

抗原

See all LSP1 抗体
LSP1 (Lymphocyte-Specific Protein 1 (LSP1))

适用

  • 111
  • 49
  • 17
  • 6
  • 4
  • 4
  • 1

宿主

  • 88
  • 26
  • 2
小鼠

克隆类型

  • 82
  • 34
单克隆

标记

  • 42
  • 7
  • 4
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
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  • 1
This LSP1 antibody is conjugated to CF®405S

应用范围

  • 85
  • 39
  • 39
  • 29
  • 29
  • 15
  • 9
  • 9
  • 9
  • 8
  • 6
  • 5
  • 2
  • 1
  • 1
  • 1
Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

克隆位点

LSP1-3025
  • 抗原表位

    • 23
    • 19
    • 16
    • 15
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 174-278

    原理

    Lymphocyte Specific Protein 1 (LSP1) / pp52(LSP1/3025), CF405S conjugate

    产品特性

    LSP1 is a hematopoietic-expressed gene that encodes an F-actin-binding, leukocyte-specific (including B and T lymphocytes, granulocytes and macrophages), phosphoprotein. However, mRNA splice variants that do not encode the lympho-specific protein are expressed from this gene in nonlymphoid cell lines as well (myocytes, stromal cells and fibroblasts), suggesting pp52 has a divergent role in signal transduction. The pp52 (LSP1) locus maps to human chromosome 11p15. 5, which is implicated in tumor-related chromosomal translocations found in chronic lymphocytic leukemia. The pp52 promoter contains key elements that control transcriptional activity including an initiator specifying the unique 5' terminus of pp52 mRNA, tandem pairs of Ets and SP1 motifs, and a single C/EBP motif. LSP1 binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions, including cell motility and chemotaxis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

    免疫原

    Recombinant fragment of human LSP1 protein (around aa174-278)

    亚型

    IgG1, kappa
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    说明

    Positive Control: Human tonsil, colon, spleen or Hodgkin lymphoma (IHC-P).

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.1 mg/mL

    缓冲液

    PBS, 0.1 % BSA, 0.05 % azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Protect from light

    储存条件

    4 °C

    储存方法

    Stable at room temperature or 37°C for 7 days.

    Protect from light

    Store at 2 to 8°C. Protect fluorescent conjugates from light

    有效期

    24 months
  • 抗原

    LSP1 (Lymphocyte-Specific Protein 1 (LSP1))

    别名

    Lymphocyte Specific Protein 1

    背景

    Synonyms: WP34, pp52, lymphocyte specific protein 1, leukocyte specific protein 1

    Gene Symbol: LSP1

    Tissue Expression: Leukocytes

    分子量

    52 kDa

    基因ID

    4046

    UniProt

    P33241
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