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Cyclin A 抗体 (Biotin)

This Biotin-conjugated 小鼠 单克隆 anti-Cyclin A antibody (Clone CCNA2-2333) specifically detects Cyclin A in IHC 和 IHC (fp). The antibody is reactive with 人 samples.
产品编号 ABIN7652728
发货至: 中国
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Quick Overview for Cyclin A 抗体 (Biotin) (ABIN7652728)

抗原

See all Cyclin A (CCNA2) 抗体
Cyclin A (CCNA2) (Cyclin A2 (CCNA2))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This Cyclin A antibody is conjugated to Biotin

应用范围

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Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

克隆位点

CCNA2-2333
  • 原理

    Cyclin A2 (S- & G2-phase Cyclin)(CCNA2/2333), Biotin conjugate

    产品特性

    Recognizes a protein of 54 kDa, which is identified as cyclin A. Its epitope is located amino acids 144-148 of human Cyclin A2. Cyclins are regulatory subunits of the cyclin-dependent kinases (cdk's) and they control transition at different specific phases of the cell cycle. The temporal expression of cyclins is tightly regulated and subsequently plays a critical role in controlling the enzymatic activity of cdk's. These cyclin/cdk complexes are essential for passage through specific stages in the cell cycle. In mammalian somatic cells, cyclin A is required for S-phase and passage through G2-phase. The D and E type cyclins regulate the passage of G1, while cyclin B is a critical regulator of mitosis. Mutation or disruption of normal cyclin A expression causes cells to arrest in G2-phase. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

    免疫原

    Full length recombinant Cyclin A2 protein

    亚型

    IgG2a, kappa
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    说明

    Positive Control: K-562 and HeLa cells, Tonsil.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.1 mg/mL

    缓冲液

    PBS, 0.1 % BSA, 0.05 % azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    Stable at room temperature or 37°C for 7 days.

    Store at 2 to 8°C. Protect fluorescent conjugates from light

    有效期

    24 months
  • 抗原

    Cyclin A (CCNA2) (Cyclin A2 (CCNA2))

    别名

    Cyclin A2

    背景

    Synonyms: CCN1, CCNA, CCNA2, Cyclin A2

    Gene Symbol: CCNA2

    分子量

    54 kDa

    基因ID

    890

    UniProt

    P20248

    途径

    PI3K-Akt Signaling, Cell Division Cycle, AMPK Signaling, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA
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