IFNB1 抗体 (AA 101-184)
Quick Overview for IFNB1 抗体 (AA 101-184) (ABIN728113)
抗原
See all IFNB1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 101-184
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交叉反应
- 人, 小鼠
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预测反应
- Rat
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from mouse IFNB1
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亚型
- IgG
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anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 22-187) antibody
IFNB1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 101-187) antibodyIFNB1 适用: 人, 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) antibodyIFNB1 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C13 unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 39-66) antibodyIFNB1 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 39-66), (N-Term) antibodyIFNB1 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB22040 unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 23-169) antibodyIFNB1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 23-169) antibodyIFNB1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C2 unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 22-187) antibodyIFNB1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 1-187) antibodyIFNB1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) (Center) antibodyIFNB1 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- IFNB1 (Interferon, beta 1, Fibroblast (IFNB1))
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别名
- IFN-beta
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背景
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Synonyms: Fibroblast interferon, N-Beta, N _, _-N, B, _ N, _N, F, N beta, NB 1, NB , NB1, Interferon beta 1 fibroblast , Beta-N, Beta N, Interferon beta precursor, MGC96956_ Interferon beta_ Interferon-beta.
Background: The mammalian type I Inteferons (IFN1) are produced in response to viral infection and other inducers. They are divided into alpha and beta subtypes leukocytes and fibroblasts reactivity. The human IFN alphas are encoded by a family of at least 15 different genes, while IFN beta is the unique member of its subtype. There is approximately 50 % amino acid homology between the alpha and beta subtypes. Both IFN subtypes are pleiotropic cytokines and have a similar range of biological activities. Differences between alpha subtypes, and between IFN alpha and betas, are in potency and cell type specific activities. In particular, IFN beta elicits a markedly higher antiproliferation response in some cell types such as, embryonal carcinoma, melanoma and melanocytes than do IFN alphas. Higher potency of IFN beta in treatment of multiple sclerosis and certain cancers has been observed. Type I IFNs signal through binding to a common cell surface receptor. Two chains of the receptor, IFNAR1 and IFNAR2, have been identified. Both chains are necessary for function and in the absence of either there is neither high affinity binding nor biological activity. The intracellular portions of the receptor subunits are bound by tyrosine kinases, Jak1 and Tyk2, members of the Janus kinase family. Upon ligand binding these kinases are activated and phosphorylate members of the STAT family of transcription factors, as well as IFNAR1 and 2.
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基因ID
- 24481
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UniProt
- P01575
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途径
- JAK/STAT Signaling, TCR Signaling, TLR signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Autophagy, Inflammasome
抗原
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